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Yung-Hsiang Kao

from San Mateo, CA
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Related to:
Yung H Kao, 61
Connected to:
Alexander C Kao, 58Benjamin J Kao, 47Beth T Kao, 45Chia P Kao, 47Chih K Kao, 63Chih P Kao, 45Collin Kao, 46Crystal J Kao, 29Dan M Kao, 67Diane Kao, 34

Yung-Hsiang Kao Phones & Addresses

  • San Mateo, CA

Publications

Us Patents

Her2 Antibody Composition

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US Patent:
7879325, Feb 1, 2011
Filed:
Jun 8, 2009
Appl. No.:
12/480013
Inventors:
Yung-Hsiang Kao - San Mateo CA, US
Martin Vanderlaan - San Francisco CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 39/395
C07K 16/00
C07K 16/30
US Classification:
4241381, 4241431, 5303888
Abstract:
A composition comprising a main species HER2 antibody that binds to domain II of HER2, and an amino acid sequence variant thereof comprising an amino-terminal leader extension is disclosed. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition are also disclosed.

Her2 Antibody Composition

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US Patent:
8241630, Aug 14, 2012
Filed:
Jan 7, 2011
Appl. No.:
12/986470
Inventors:
Yung-Hsiang Kao - San Mateo CA, US
Martin Vanderlaan - San Francisco CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 39/395
US Classification:
4241381, 4241431
Abstract:
A composition comprising a main species HER2 antibody that binds to domain II of HER2, and an amino acid sequence variant thereof comprising an amino-terminal leader extension is disclosed. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition are also disclosed.

Prevention Of Disulfide Bond Reduction During Recombinant Production Of Polypeptides

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US Patent:
8574869, Nov 5, 2013
Filed:
Jan 19, 2012
Appl. No.:
13/354223
Inventors:
Yung-Hsiang Kao - San Mateo CA, US
Michael W. Laird - San Ramon CA, US
Melody Trexler Schmidt - San Carlos CA, US
Rita L. Wong - Redwood City CA, US
Daniel P. Hewitt - Sunnyvale CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12P 1/00
C12N 5/02
US Classification:
435 41, 435325
Abstract:
Provided herein are methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

Her2 Antibody Composition

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US Patent:
20060018899, Jan 26, 2006
Filed:
Jul 15, 2005
Appl. No.:
11/182908
Inventors:
Yung-Hsiang Kao - San Mateo CA, US
Martin Vanderlaan - San Francisco CA, US
International Classification:
A61K 39/395
US Classification:
424133100, 424155100
Abstract:
A composition comprising a main species HER2 antibody that binds to domain II of HER2, and an amino acid sequence variant thereof comprising an amino-terminal leader extension is disclosed. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition are also disclosed.

Prevention Of Disulfide Bond Reduction During Recombinant Production Of Polypeptides

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US Patent:
20090053786, Feb 26, 2009
Filed:
Jul 8, 2008
Appl. No.:
12/217745
Inventors:
Yung-Hsiang Kao - San Mateo CA, US
Michael W. Laird - San Ramon CA, US
Melody Trexler Schmidt - San Carlos CA, US
Rita L. Wong - Redwood City CA, US
Daniel P. Hewitt - Sunnyvale CA, US
International Classification:
C12N 9/99
C12N 5/06
US Classification:
435184, 435375, 435358, 4352523, 43525233
Abstract:
The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

Pertuzumab Variants And Evaluation Thereof

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US Patent:
20230047103, Feb 16, 2023
Filed:
Jun 27, 2022
Appl. No.:
17/809098
Inventors:
- South San Francisco CA, US
Yung-Hsiang Kao - San Mateo CA, US
Yonghua Zhang - Foster City CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 16/30
G01N 33/68
C07K 16/32
Abstract:
The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.

Pertuzumab Variants And Evaluation Thereof

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US Patent:
20200157238, May 21, 2020
Filed:
Aug 6, 2019
Appl. No.:
16/533488
Inventors:
- South San Francisco CA, US
Yung-Hsiang Kao - San Mateo CA, US
Yonghua Zhang - Foster City CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 16/30
G01N 33/68
C07K 16/32
Abstract:
The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.

Pertuzumab Variants And Evaluation Thereof

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US Patent:
20190345258, Nov 14, 2019
Filed:
Jul 12, 2019
Appl. No.:
16/510287
Inventors:
- South San Francisco CA, US
Yung-Hsiang Kao - San Mateo CA, US
Yonghua Zhang - Foster City CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 16/30
C07K 16/32
G01N 33/68
Abstract:
The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof
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Yung-Hsiang Kao from San Mateo, CA Get Report