Peter H Dobbelaar

8183275, May 22, 2012

Oct 16, 2007

12/311672

Peter H. Dobbelaar - Morris Plains NJ, US
Christopher L. Franklin - Keasbey NJ, US
Allan Goodman - Media PA, US
Cheng Guo - Schenectady NY, US
Peter R. Guzzo - Niskayuna NY, US
Mark Hadden - Albany NY, US
Shuwen He - Edison NJ, US
Alan J. Henderson - Albany NY, US
Tianying Jian - Westfield NJ, US
Linus S. Lin - Westfield NJ, US
Jian Liu - Edison NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Megan Ruenz - Grayslake IL, US
Bruce J. Sargent - Delmar NY, US
Iyassu K. Sebhat - Jersey City NJ, US
Larry Yet - Albany NY, US

Merck Sharp & Dohme Corp. - Rahway NJ
Albany Molecular Research, Inc. - Albany NY

A61K 31/4178
A61K 31/4164
C07D 471/04
C07D 401/10
C07D 403/10
C07D 233/64

514393, 514360, 514385, 514387, 514390, 548126, 5483001, 548416, 548578, 546113, 5462727, 544333, 544405

Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

20090325990, Dec 31, 2009

Oct 13, 2006

12/083567

Raman K. Bakshi - Edison NJ, US
James P. Dellureficio - Millington NJ, US
Peter H. Dobbelaar - Morris Plains NJ, US
Liangqin Guo - Edison NJ, US
Shuwen He - Edison NJ, US
Qingmei Hong - Scotch Plains NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Zhixiong Ye - West Windsor NJ, US

A61K 31/438
C07D 491/107
C07D 405/14

514278, 546 17

Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

20100184758, Jul 22, 2010

Jul 15, 2008

12/668822

Peter H. Dobbelaar - Morris Plains NJ, US
Wu Du - Monroe Township NJ, US
Liangqin Guo - Edison NJ, US
William K. Hagmann - Westfield NJ, US
Shuwen He - Edison NJ, US
Tianying Jian - Westfield NJ, US
Jian Liu - Edison NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Alexander Pasternak - Princeton NJ, US
Shrenik K. Shah - Metuchen NJ, US
Quang T. Truong - Morganville NJ, US
Zhixiong Ye - Princeton NJ, US
Raman Bakshi - Edison NJ, US

A61K 31/5377
C07D 471/14
A61K 31/437
C07D 413/14
C07D 403/14
A61K 31/501
A61K 31/4995
A61K 31/506
A61P 3/10
A61P 3/04
A61P 3/00
A61P 3/06
A61P 9/12

5142328, 546 84, 514292, 544126, 544238, 51425204, 544361, 51425303, 544333, 514256, 544315, 514274

Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.