Patrick M Lippiello from Ponte Vedra, FL, age 74

Pharmaceutical Compositions And Methods For Effecting Dopamine Release

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US Patent:

6525065, Feb 25, 2003

Filed:

Jun 30, 1997

Appl. No.:

08/885397

Inventors:

William Scott Caldwell - Winston-Salem NC
Merouane Bencherif - Winston-Salem NC
Gary Maurice Dull - Lewisville NC
Peter Anthony Crooks - Lexington KY
Patrick Michael Lippiello - Lewisville NC

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

A61K 3146

US Classification:

514305, 514299, 514300, 514277, 514256, 546137

Abstract:

Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e. g. , Parkinsonism, Parkinsons Disease, Tourettes Syndrome, attention deficient disorder, or schizophrenia) are treated by administering an endo or exo form of a 1-aza-2-(3-pyridyl)bicyclo[2. 2. 1]heptane, a 1-aza-2-(3-pyridyl)bicyclo[2. 2. 2]octane, a 1-aza-2-(3-pyridyl)bicyclo[3. 2. 2]nonane, a 1-aza-7-(3-pyridyl)bicyclo[2. 2. 1]heptane, a 1-aza-3-(3-pyridyl)bicyclo[3. 2. 2]nonane, or a 1-aza-7-(3-pyridyl)bicyclo[3. 2. 2]nonane.

Compounds Capable Of Activating Cholinergic Receptors

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US Patent:

6979695, Dec 27, 2005

Filed:

Oct 2, 2002

Appl. No.:

10/263083

Inventors:

William S. Caldwell - Winston Salem NC, US
Gary M. Dull - Lewisville NC, US
Balwinder S. Bhatti - Winston-Salem NC, US
Srishailkumar B. Hadimani - Oak Creek WI, US
Haeil Park - Kangwon-do, KR
Jared M. Wagner - Stillwater OK, US
Peter A. Crooks - Nicholasville KY, US
Patrick M. Lippiello - Lewisville NC, US
Merouane Bencherif - Winston-Salem NC, US

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

C07D213/38
C07D213/65
A61K031/44
A61K031/4427
A61P025/28

US Classification:

514344, 514345, 514357, 544300, 544297

Abstract:

The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.

Compounds Capable Of Activating Cholinergic Receptors

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US Patent:

7045538, May 16, 2006

Filed:

Oct 22, 2004

Appl. No.:

10/971543

Inventors:

William S. Caldwell - Winston Salem NC, US
Gary M. Dull - Lewisville NC, US
Balwinder S. Bhatti - Winston-Salem NC, US
Srishailkumar B. Hadimani - Oak Creek WI, US
Haeil Park - Kangwon-do, KR
Jared M. Wagner - Stillwater OK, US
Peter A. Crooks - Nicholasville KY, US
Patrick M. Lippiello - Lewisville NC, US
Merouane Bencherif - Winston-Salem NC, US

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

C07D 213/38
A61K 31/44
A61P 29/02

US Classification:

514351, 546290, 546297

Abstract:

The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.

Compounds Capable Of Activating Cholinergic Receptors

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US Patent:

20060293289, Dec 28, 2006

Filed:

Mar 28, 2006

Appl. No.:

11/277664

Inventors:

William Caldwell - Winston Salem NC, US
Gary Dull - Lewisville NC, US
Balwinder Bhatti - Winston-Salem NC, US
Srishailkumar Hadimani - Oak Creek WI, US
Haeil Park - Chuncheon, KR
Jared Wagner - Stillwater OK, US
Peter Crooks - Nicholasville KY, US
Patrick Lippiello - Lewisville NC, US
Merouane Bencherif - Winston-Salem NC, US

International Classification:

A61K 31/513
A61K 31/506
A61K 31/655
C07D 239/42
C07D 403/02

US Classification:

514151000, 514256000, 514269000, 514275000, 544296000, 544310000, 544330000

Abstract:

The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.

Compounds Capable Of Activating Cholinergic Receptors

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US Patent:

20100121061, May 13, 2010

Filed:

Dec 8, 2009

Appl. No.:

12/633308

Inventors:

William S. Caldwell - Winston Salem NC, US
Gary M. Dull - Lewisville NC, US
Balwinder S. Bhatti - Winston-Salem NC, US
Srishailkumar B. Hadimani - Oak Creek WI, US
Haeil Park - Kangwon-do, KR
Jared M. Wagner - Stillwater OK, US
Peter A. Crooks - Nicholasville KY, US
Patrick M. Lippiello - Lewisville NC, US
Merouane Bencherif - Winston-Salem NC, US

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

C07D 239/26
C07D 213/55
C07D 213/65
C07D 213/73
C07D 213/02

US Classification:

544335, 546335, 546300, 546311

Abstract:

The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.

Methods For Preventing The Development Of Retinopathy By The Oral Administration Of Nnr Ligands

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US Patent:

20110098312, Apr 28, 2011

Filed:

May 11, 2009

Appl. No.:

12/992115

Inventors:

Merouane Bencherif - Winston-Salem NC, US
Scott N. Cullison - Winston-Salem NC, US
Patrick M. Lippiello - Lewisville NC, US
Steven M. Toler - Winston-Salem NC, US

Assignee:

Targacept ,Inc - Winston-Salem NC

International Classification:

A61K 31/506
A61P 27/02
A61K 31/439

US Classification:

514256, 514305

Abstract:

Method and compositions for delaying the onset or progression of retinopathy, including administering at least one neuronal nicotinic ligand are disclosed.

Arylvinylazacycloalkane Compounds For Constipation

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US Patent:

20130237550, Sep 12, 2013

Filed:

Mar 4, 2011

Appl. No.:

13/583644

Inventors:

Steven M. Toler - Winston-Salem NC, US
David Hosford - Durham NC, US
Patrick M. Lippiello - Lewisville NC, US
Geoffrey Charles Dunbar - Winston-Salem NC, US
William Scott Caldwell - Winston-Salem NC, US
Parviz Hamedani - Califon, NJ
Merouane Bencherif - Winston-Salem NC, US

Assignee:

TARGACEPT, INC. - Winston-Salem NC

International Classification:

A61K 31/506
A61K 45/06

US Classification:

514256

Abstract:

The present invention relates to method of treating constipation and enhancing colonic motility by administration of 5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine or a pharmaceutically acceptable salt thereof.

Method For Treatment Of Neurodegenerative Diseases

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US Patent:

52273857, Jul 13, 1993

Filed:

Mar 13, 1992

Appl. No.:

7/850624

Inventors:

William S. Caldwell - Winston-Salem NC
Huw M. L. Davies - Clemmons NC
Patrick M. Lippiello - Clemmons NC

Assignee:

Wake Forest University - Winston-Salem NC
R. J. Reynolds Tobacco Company - Winston-Salem NC

International Classification:

A61K 3144

US Classification:

514304

Abstract:

Patients suffering from neurodegenerative diseases are treated by administering an effective amount of a ferruginine compound or a anhydroecgonine compound.