Inventors:
- Berkeley CA, US
Hassan Issafras - Berkeley CA, US
Agnes Choppin Holmes - Berkeley CA, US
Kirk W. Johnson - Berkeley CA, US
Amer M. Mirza - Berkeley CA, US
Daniel H. Bedinger - Berkeley CA, US
Rachel A. Hunt - Berkeley CA, US
Toshihiko Takeuchi - Berkeley CA, US
Kiranjit Kaur Ahluwalia - Berkeley CA, US
Robyn Cotter - Berkeley CA, US
International Classification:
C07K 16/44
C07K 16/26
A61K 38/02
A61K 39/395
Abstract:
The present disclosure relates, in general, human antibodies against human parathyroid hormone receptor 1 (PTH1R) and methods of use of such antibodies in the treatment of cancer, Humoral Hypercalcemia of Malignancy (HHM), or Primary Hyperparathyroidism (PHPT) and Secondary Hyperparathyroidism (SHPT) and cachexia.