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Iwona E Wrona

from Sharon, MA
Age ~44
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Related to:
Krystyna Wrona, 79Klaudia Wrona Jawilak, 43Guadalupe Garcia, 48Teresa Cervantes, 47
Connected to:
Annette E Wrona, 52Carianne M Wrona, 48Christopher D Wrona, 43Joann A Wrona, 68Katie Wrona, 58Margaret A Wrona, 82Marty L Wrona, 41Rivki Wrona, 57Sebastian Wrona, 38Timothy M Wrona, 56

Iwona Wrona Phones & Addresses

  • 17 Harding St, Sharon, MA 02067
  • 37 Myrtle St, Chicopee, MA 01013 (413) 594-5710
  • Chestnut Hill, MA
  • Brookline, MA
  • Worcester, MA

Work

Company: Cubist pharmaceuticals Feb 2009 Position: Scientist

Education

School / High School: Boston University 2002 to 2008

Skills

Drug Discovery • Organic Chemistry • Organic Synthesis • Medicinal Chemistry • Chemistry • Hplc • Pharmaceutical Industry • Nmr • Life Sciences • Lc Ms • Drug Development • Chromatography • Validation • Biotechnology

Languages

English • Polish

Industries

Biotechnology

Resumes

Resumes

Iwona Wrona Photo 1

Director

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Location:
17 Harding St, Sharon, MA 02067
Industry:
Biotechnology
Work:
Cubist Pharmaceuticals since Feb 2009
Scientist
Schering-Plough Research Institute May 2008 - Jan 2009
Senior Scientist
Education:
Boston University 2002 - 2008
College of the Holy Cross 1998 - 2002
BA, Chemistry
Skills:
Drug Discovery
Organic Chemistry
Organic Synthesis
Medicinal Chemistry
Chemistry
Hplc
Pharmaceutical Industry
Nmr
Life Sciences
Lc Ms
Drug Development
Chromatography
Validation
Biotechnology
Languages:
English
Polish

Publications

Us Patents

Pyrazolo[1,5-A]Pyrimidine Derivatives As Mtor Inhibitors

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US Patent:
20120114739, May 10, 2012
Filed:
Apr 8, 2010
Appl. No.:
13/263193
Inventors:
Yongqi Deng - Newton MA, US
Binyuan Sun - Chestnut Hill MA, US
Hongbo Zeng - Westford MA, US
Matthew Richards - Somerville MA, US
Cliff C. Cheng - Cambridge MA, US
Yinyan Zhao - Rockville MD, US
Andrew McRiner - Melrose MA, US
Zhaoyang Meng - Lansdale PA, US
Yang Nan - Lansdale PA, US
Mehul F. Patel - Willow Grove PA, US
Iwona E. Wrona - Sharon MA, US
Panduranga Adulla Reddy - Walpole MA, US
Brian M. Eklov - Kalamazoo MI, US
Shuyi Tang - Belmont MA, US
Duan Liu - Arlington MA, US
Amit K. Mandal - Shrewsbury MA, US
Lianyun Zhao - Blue Bell PA, US
M. Asshad Siddiqui - Newton MA, US
International Classification:
A61K 9/127
A61K 31/519
A61K 31/5377
C07D 491/048
C07D 495/04
A61K 31/538
A61K 31/551
A61K 31/553
A61K 31/541
A61K 31/554
C07D 498/04
C12N 9/99
A61K 31/704
A61K 39/395
A61K 33/36
A61K 38/50
A61K 33/24
A61P 29/00
A61P 37/08
A61P 11/00
A61P 37/06
A61P 35/00
A61P 35/02
C07D 487/04
US Classification:
424450, 544281, 5142593, 544117, 5142332, 544230, 544238, 51425202, 51425505, 544105, 5142305, 540492, 514218, 514249, 540544, 51421115, 544 61, 5142285, 540575, 51425216, 544 582, 51421016, 51421018, 435184, 514 34, 4241381, 424623, 424 946, 4241331, 424649
Abstract:
The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.

Compounds And Uses Thereof

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US Patent:
20220298168, Sep 22, 2022
Filed:
Sep 22, 2020
Appl. No.:
17/028778
Inventors:
- Cambridge MA, US
Matthew LUCAS - Lexington MA, US
Kerem OZBOYA - Cambridge MA, US
Bhaumik PANDYA - Bedford MA, US
Daniel TARDIFF - Arlington MA, US
Parcharee TIVITMAHAISOON - Boston MA, US
Iwona WRONA - Sharon MA, US
International Classification:
C07D 491/107
C07D 237/04
C07D 401/12
C07D 237/24
C07D 213/82
C07D 403/12
C07D 409/14
C07D 487/04
C07D 401/14
C07D 471/04
C07D 405/14
C07D 413/12
C07D 417/12
C07D 513/04
C07D 417/14
C07D 495/04
Abstract:
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Compounds And Uses Thereof

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US Patent:
20230078764, Mar 16, 2023
Filed:
Mar 20, 2020
Appl. No.:
17/441937
Inventors:
- Boston MA, US
Matthew LUCAS - Lexington MA, US
Kerem OZBOYA - Cambridge MA, US
Bhaumik PANDYA - Bedford MA, US
Daniel TARDIFF - Arlington MA, US
Parcharee TIVITMAHAISOON - Boston MA, US
Iwona WRONA - Sharon MA, US
International Classification:
A61K 31/4439
A61K 31/495
A61K 31/17
A61K 31/436
A61K 31/475
A61K 31/166
A61K 39/395
C07D 401/12
C07D 495/04
C07D 417/12
C07D 405/14
C07D 413/12
C07D 401/14
C07D 213/75
A61K 31/501
A61K 31/506
A61K 31/444
A61K 31/497
A61K 31/519
A61K 31/44
Abstract:
The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

Compounds And Uses Thereof

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US Patent:
20200262828, Aug 20, 2020
Filed:
Oct 24, 2018
Appl. No.:
16/758495
Inventors:
- Cambridge MA, US
Bertrand LE BOURDONNEC - Northborough MA, US
Iwona WRONA - Sharon MA, US
Bhaumik PANDYA - Bedford MA, US
Parcharee TIVITMAHAISOON - Boston MA, US
Kerem OZBOYA - Cambridge MA, US
Benjamin VINCENT - Cambridge MA, US
Daniel TARDIFF - Arlington MA, US
Jeff PIOTROWSKI - Somerville MA, US
Eric SOLIS - Milford MA, US
Robert SCANNEVIN - Hopkinton MA, US
Rebecca ARON - Cambridge MA, US
Kenneth RHODES - Belmont MA, US
International Classification:
C07D 413/14
C07D 413/04
C07D 417/04
C07D 417/14
C07D 471/04
C07D 271/07
C07D 413/10
C07D 487/04
C07D 487/10
Abstract:
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Compounds And Uses Thereof

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US Patent:
20200010462, Jan 9, 2020
Filed:
Oct 24, 2017
Appl. No.:
16/344195
Inventors:
- Cambridge MA, US
Bertrand LE BOURDONNEC - Northborough MA, US
Iwona WRONA - Sharon MA, US
Bhaumik PANDYA - Bedford MA, US
Parcharee TIVITMAHAISOON - Boston MA, US
Kerem OZBOYA - Cambridge MA, US
Benjamin VINCENT - Cambridge MA, US
Daniel TARDIFF - Arlington MA, US
Jeff PIOTROWSKI - Somerville MA, US
Eric SOLIS - Milford MA, US
Robert SCANNEVIN - Hopkinton MA, US
Rebecca ARON - Cambridge MA, US
Kenneth Rhodes - Belmont MA, US
International Classification:
C07D 413/14
C07D 413/04
C07D 417/04
C07D 417/14
C07D 471/04
Abstract:
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Inhibiting The Transient Receptor Potential A1 Ion Channel

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US Patent:
20180230149, Aug 16, 2018
Filed:
Mar 29, 2018
Appl. No.:
15/940253
Inventors:
- Cambridge MA, US
Xinyuan Wu - Newton MA, US
Qingyi Li - Somerville MA, US
Iwona Wrona - Sharon MA, US
Andrew J. Jackson - Waltham MA, US
Bertrand L. Chenard - Waterford CT, US
Christopher M. Liu - Somerville MA, US
Guohua Liang - Acton MA, US
Matthew F. Baevsky - Northborough MA, US
Richard A. Earl - Westford MA, US
Lisa Mcqueen - Phoenixville PA, US
Jared Smit - Lafayette IN, US
Brett A. Cowans - Lafayette IN, US
International Classification:
C07D 473/08
Abstract:
The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition thereof, and their use for the treatment of pain, inflammatory disease, neuropathy, dermatological disorders, pulmonary conditions, and cough, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).

Inhibiting The Transient Receptor Potential A1 Ion Channel

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US Patent:
20170050966, Feb 23, 2017
Filed:
Apr 23, 2015
Appl. No.:
15/305892
Inventors:
- Cambridge MA, US
Xinyuan Wu - Newton MA, US
Qingyi Li - Somerville MA, US
Iwona Wrona - Sharon MA, US
Andrew J. Jackson - Waltham MA, US
Bertrand L. Chenard - Waterford CT, US
Christopher Matthew Liu - Somerville MA, US
Guohua Liang - Acton MA, US
Matthew F. Baevsky - Northborough MA, US
Richard Alan Earl - Westford MA, US
Lisa Mcqueen - Phoenixville PA, US
Jared Smit - Lafayette IN, US
Brett A. Cowans - West Lafayette IN, US
International Classification:
C07D 473/08
Abstract:
The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition thereof, and their use for the treatment of pain, inflammatory disease, neuropathy, dermatological disorders, pulmonary conditions, and cough, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).

Inhibiting The Transient Receptor Potential A1 Ion Channel

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US Patent:
20140206650, Jul 24, 2014
Filed:
Jan 21, 2014
Appl. No.:
14/160333
Inventors:
- Lexington MA, US
Qingyi Li - Somerville MA, US
Lily Cheng - Chestnut Hill MA, US
Christopher M. Liu - Somerville MA, US
Iwona E. Wrona - Sharon MA, US
Andrew J. Jackson - Waltham MA, US
International Classification:
C07F 9/09
C07D 473/08
US Classification:
514 81, 544244, 544270, 51425505, 51426321
Abstract:
This disclosure describes novel compounds and pharmaceutical compositions for inhibiting the TRPA1 ion channel and/or medical conditions related to TRPA1, such as pain and respiratory conditions.
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Iwona E Wrona from Sharon, MA, age ~44 Get Report