US Patent:
20030199446, Oct 23, 2003
Inventors:
Joachim Bunger - Gross-Umstadt, DE
Francois Marchio - Scarsdale NY, US
International Classification:
A61K038/17
A61K048/00
US Classification:
514/012000, 514/044000, 514/269000
Abstract:
This invention relates to the use of at least one compound, selected from a compound of the formula 1a, 1b, a physiologically compatible salt of it and a stereoisomeric form of it, whereby the following signify RH or alkyl, RH, COOH, COO-alkyl or CO—NH—R, Rand Reach mutually independent H or OH, n 1, 2 or 3, RH, alkyl, an amino acid residue, a dipeptide residue or tripeptide residue, and alkyl an alkyl residue with 1 to 4 carbon atoms, for the stabilisation of p53. According to the invention, these compounds are normally used in the form of a topical composition.