Inventors:
Falguni Dasgupta - San Leandro CA
John H. Musser - San Carlos CA
Daniel E. Levy - Oakland CA
Peng Cho Tang - Moraga CA
Assignee:
Glycomed Incorporated - Alameda CA
International Classification:
A61K 31715
A61K 3814
C07H 306
C07K 200
Abstract:
Compounds that exhibit selectin binding activity are described and have the following structural formula: ##STR1## where W is selected from a group including structures a-d below ##STR2## wherein p is an integer of from 0-2, q is an integer of from 0-3, and r is an integer of from 0-5; A is selected from the group consisting of. alpha. and. beta. forms of sialic acid, Kemp's acid, quinic acid, R and S forms of mandelic acid, R and S forms of glyceric acid, R and S forms of lactic acid, propionic and acetic acid, and esters and amides thereof, --SO. sub. 3, sulfonate, --PO. sub. 3, phosphonate, trifluoromethyl, diazine and triazine; B is selected from a group consisting of. alpha. and. beta. forms of fucose, arabinose and esters and substituted forms thereof wherein one or more of the OH groups is independently substituted with F, N. sub. 3, NHAc, NHCOCF. sub. 3.