Inventors:
Aaron K. Sato - Richmond CA, US
Daniel J. Sexton - Melrose MA, US
Daniel T. Dransfield - Hanson MA, US
Robert C. Ladner - Ijamsville MD, US
Christophe Arbogast - Viuz-en-Sallaz, FR
Philippe Bussat - La Roche-sur-Foron, FR
Hong Fan - PuDong, CN
Sudha Khurana - San Jose CA, US
Karen E. Linder - Kingston NJ, US
Edmund R. Marinelli - Lawrenceville NJ, US
Palaniappa Nanjappan - Princeton NJ, US
Adrian D. Nunn - Lambertville NJ, US
Radhakrishna K. Pillai - Cranbury NJ, US
Sibylle Pochon - Troinex, CH
Feng Yan - Grand-Lancy, CH
Ajay Shrivastava - Princeton NJ, US
Bo Song - Princeton NJ, US
Rolf E. Swenson - Princeton NJ, US
Mathew A. Von Wronski - Moorestown NJ, US
Assignee:
Dyax Corp. - Burlington MA
Bracco Suisse SA - Manno
International Classification:
A61K 49/00
A61B 8/00
Abstract:
The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e. g. , having a K
