Inventors:
Anne M. Kask - Bakerton WV
Concepcio Marin - Bethesda MD
Assignee:
The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC
International Classification:
A61K 4900
A61K 3154
A01N 4304
Abstract:
A method for reversing or preventing the onset of tolerance and the development of extrapyramidal side effects in humans due to prolonged treatment with neuroleptics, comprising including S-adenosyl-L-methionine (SAMe) in the treatment regime. By utilizing SAMe in combination with tolerance-inducing neurolepitcs to maintain a minimum dosage of the drug while retaining its efficacy, the potential for the development of neuroleptic-induced, extrapyramidal side effects is minimized.