Zhongyun Y Dong

7829575, Nov 9, 2010

Apr 17, 2007

11/787593

Zhongyun Dong - Cincinnati OH, US
Shan Lu - Cincinnati OH, US

University of Cincinnati - Cincinnati OH

A61K 31/513

514274

One embodiment is directed toward a method for treating an individual with a disorder affected by androgen receptor activity. This method includes administering a therapeutic amount of DL3 (6-amino-2-(2-4-tert-butyl-phenoxy)-ethylsulfanyl)-1H-pyrimidin-4-one) to the individual. In an additional embodiment, the disorder affected by androgen receptor activity includes cancer. Another embodiment is directed toward a method for treating an individual with prostate cancer. This method includes administering to the individual a therapeutic amount of an androgen receptor antagonist which reduces the production of prostate specific antigen and has only negligible androgen receptor agonist effects.

20030206890, Nov 6, 2003

May 31, 2001

09/872162

Isaiah Fidler - Houston TX, US
Zhongyun Dong - Sugar Land TX, US
Weixin Lu - Houston TX, US

A61K048/00
A61K038/20

424/093210, 424/085200

Disclosed are methods and compositions useful in the recruitment, activation and initiation of proliferation of immune cells. The instant invention relates to the discovery that specific insect cells and insect cell compositions exhibit adjuvant properties. The added benefit of this system is that the insect cells utilized may be transformed with an expression system and thus proteins may be introduced into the composition through direct protein expression by the cells. The claimed compositions and methods are particularly relevant in anti-tumor and cancer therapy. Of specific interest is the ability of the compositions of the invention to elicit a response that controls not only the primary tumor but also any metastatic cells or metastatic tumors which subsequently arise.

20050232906, Oct 20, 2005

Mar 29, 2005

11/093269

Isaiah Fidler - Houston TX, US
Zhongyun Dong - Sugar Land TX, US
Weixin Lu - Houston TX, US

A61K048/00
A61K038/21
A61K038/20
C12N015/86
C12N005/08

424093210, 435366000, 435455000, 424085200, 424085700

Disclosed are methods and compositions useful in the recruitment, activation and initiation of proliferation of immune cells. The instant invention relates to the discovery that specific insect cells and insect cell compositions exhibit adjuvant properties. The added benefit of this system is that the insect cells utilized may be transformed with an expression system and thus proteins may be introduced into the composition through direct protein expression by the cells. The claimed compositions and methods are particularly relevant in anti-tumor and cancer therapy. Of specific interest is the ability of the compositions of the invention to elicit a response that controls not only the primary tumor but also any metastatic cells or metastatic tumors which subsequently arise.

20060228326, Oct 12, 2006

Oct 21, 2003

10/532551

Isaiah Fidler - Houston TX, US
Zhongyun Dong - Sugar Land TX, US
Weixin Lu - Houston TX, US

A61K 38/21
A61K 38/20
A61K 38/19
C12P 21/02
C12N 5/06

424085100, 424085200, 424085500, 424085600, 424085700, 435069500, 435348000

The present invention provides for the treatment of a subject with occult brain metastasis. The treatment relies on administering to the subject a composition comprising an immunomodulatory polypeptide and a baculovirus-insect cell preparation. This composition has a unique ability to generate an anti-tumor immune response that is able to cross the blood-brain barrier.

20070054908, Mar 8, 2007

Sep 1, 2006

11/515052

Zhongyun Dong - Cincinnati OH, US
Shan Lu - Cincinnati OH, US

A61K 31/5375
A61K 31/445

514237500, 514317000

Pharmaceutical compositions comprising a chemotherapeutic agent comprising one of the previously unknown antineoplastic agents, DL-001 or DL-002 and methods for inhibiting tumor cell proliferation, inducing tumor cell death by apoptosis and inhibiting growth of a drug resistant tumor comprising administration of the inventive compositions are provided. Successfully treated tumors include epithelial cell-derived malignancies and a broad spectrum of tumors, including drug resistant tumors. In particular, the inventive compositions retain efficacy in tumors exhibiting multiple drug resistance.

20140018385, Jan 16, 2014

Sep 8, 2011

13/821789

Zhongyun Dong - Cincinnati OH, US
Matthew Wortman - Fort Wright KY, US
Kelsey Dillehay - Cincinnati OH, US

UNIVERSITY OF CINCINNATI - Cincinnati OH

A61K 31/4704
A61K 31/415
A61K 31/166
A61K 31/381

514312, 435375, 435366, 435363, 435350, 435354, 514448, 514406, 514615, 514443, 435351

Pharmaceutical compositions and methods for inhibiting cell growth, modulating function of PCNA, treating prostate cancer, and enhancing PCNA trimer formation are disclosed. The methods include administering an effective amount of a compound of Formula (I), Formula (II)