Inventors:
Todd G. Kirchgessner - Flemington NJ, US
Bonnie Hsiang - Pennington NJ, US
Yingjie Zhu - Killingworth CT, US
Yuli Wu - Newtown PA, US
Zhaoqing Wang - Piscataway NJ, US
Jean S. Lynch - Ringoes NJ, US
Xin Huang - Princeton NJ, US
Wen-Pin Yang - Princeton NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 1/00
C07K 14/00
C12P 21/06
C12P 21/04
Abstract:
The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.
