Yuh-Min Chiang

20070014695, Jan 18, 2007

Apr 26, 2006

11/380327

Min Yue - Belmont CA, US
David Liu - Los Altos CA, US
Yuh-Min Chiang - Foster City CA, US
Joon Mo Yang - Redwood City CA, US
Dennis Lehto - Santa Clara CA, US
Charles Vann - El Granada CA, US
Nigel Beard - Redwood City CA, US
Ian Harding - San Mateo CA, US
John Van Camp - San Ramon CA, US
Alexander Dromaretsky - Davis CA, US
Sergey Ermakov - Hayward CA, US
Mark Oldham - Los Gatos CA, US
Joy Roy - San Jose CA, US
Maryam Shariati - Sunnyvale CA, US
Umberto Ulmanella - Foster City CA, US

Applera Corporation - Foster City CA

B01L 3/00

422100000

Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.

20070280857, Dec 6, 2007

Jun 2, 2006

11/422058

Maengseok Song - Burlingame CA, US
Joon Mo Yang - Redwood City CA, US
Julie C. Lee - Sunnyvale CA, US
Nigel P. Beard - Redwood City CA, US
Yuh-Min Chiang - Foster City CA, US
Roy H. Tan - Union City CA, US
Carol Schembri - San Mateo CA, US

APPLERA CORPORATION - Foster City CA

B01L 3/02

422100

A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers. At least some of the sample chambers may include a dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.

20080293127, Nov 27, 2008

May 22, 2007

11/752243

Yuh-Min Chiang - Foster City CA, US
Aldrich N.K. Lau - Palo Alto CA, US

Applera Corporation - Foster City CA

C08J 3/00
C12M 1/00

4352831, 528503

A method for substantially eliminating a cross-linking element of a pressure sensitive adhesive by heating the pressure sensitive adhesive at a temperature of at least 180 C. for a period of time required to thermally decompose the cross-linking element of the pressure sensitive adhesive.

20090081768, Mar 26, 2009

Sep 21, 2007

11/859180

Joon Mo Yang - Redwood City CA, US
David M. Liu - Los Altos CA, US
Yuh-Min Chiang - Foster City CA, US
Carol Schrembri - San Mateo CA, US
Aldrich N.K. Lau - Palo Alto CA, US
Umberto Ulmanella - Foster City CA, US
Nigel P. Beard - Redwood City CA, US
Maryam Shariati - Sunnyvale CA, US
James C. Nurse - Pleasanton CA, US
Douwe D. Haga - Redwood City CA, US
Ian A. Harding - San Mateo CA, US
Julio P. Focaracci - San Mateo CA, US

Applera Corporation - Foster City CA

C12M 1/34
B29C 59/02
B29C 59/16

4352884, 264293, 264442, 264101

An assay card and devices and methods for isolating chambers on the assay card are described. The assay card comprises a substrate formed of one or more materials, e.g., plastic, having a softening temperature, the substrate defining channels communicating with respective reaction chambers. The assay card may be heated in a region of the channels to at least the softening temperature. The softened plastic may be deformed, e.g., with a tool which may or may not also provide the heat for softening the substrate. In this manner, the plastic of the substrate may be caused to at least partially obstruct the channels, thereby isolating the reaction chambers. The invention also relates to a method of manufacturing a tool device that includes pins for heating and deforming an assay card.

20110020179, Jan 27, 2011

May 27, 2010

12/789363

Min Yue - Belmont CA, US
David M. Liu - Los Altos CA, US
Yuh-Min Chiang - Sunnyvale CA, US
Joon-Mo Yang - Redwood City CA, US
Dennis Lehto - Santa Clara CA, US
Charles S. Vann - Marietta GA, US
Nigel P. Beard - Redwood City CA, US
Ian A. Harding - San Mateo CA, US
John Van Camp - San Ramon CA, US
Alexander Dromaretsky - Davis CA, US
Sergey V. Ermakov - Hayward CA, US
Mark F. Oldham - Foster City CA, US
Joy Roy - San Jose CA, US
Maryam Shariati - Sunnyvale CA, US
Umberto Ulmanella - Foster City CA, US

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA

G01N 33/00

422 63

Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.

20110177562, Jul 21, 2011

Dec 20, 2010

12/973190

Charles S. Vann - El Dorado Hills CA, US
Michael Greenstein - Los Altos CA, US
Yuh-Min Chiang - Sunnyvale CA, US

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA

C12P 19/34
G01N 27/447

435 912, 204518

The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.

20180016624, Jan 18, 2018

Jul 24, 2017

15/658016

- Carlsbad CA, US
David M. LIU - Los Altos CA, US
Joy ROY - San Jose CA, US
Yuh-Min CHIANG - Sunnyvale CA, US
Joon Mo YANG - Redwood City CA, US
Dennis LEHTO - Santa Clara CA, US
Charles S. VANN - El Granada CA, US
Nigel P. BEARD - San Diego CA, US
Ian A. HARDING - San Mateo CA, US
John R. Van Camp - San Ramon CA, US
Alexander DROMARETSKY - Davis CA, US
Sergey V. ERMAKOV - Castro Valley CA, US
Mark F. OLDHAM - Emerald Hills CA, US
Maryam SHARIATI - Foster City CA, US
Umberto ULMANELLA - Foster City CA, US

C12Q 1/68
G01N 35/02
B01L 3/00

Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.

20150140611, May 21, 2015

Oct 20, 2014

14/518625

- Carlsbad CA, US
Michael Greenstein - Los Altos CA, US
Yuh-Min Chiang - Sunnyvale CA, US

G01N 27/447
C12Q 1/68

435 912, 204450

The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.