Inventors:
Paul Webster - Pasadena CA, US
Siva Wu - South Pasadena CA, US
James Kerwin - Moss Beach CA, US
Assignee:
HOUSE RESEARCH INSTITUTE - Los Angeles CA
International Classification:
G01N 33/573
C40B 40/10
C40B 30/04
G01N 27/72
A61K 39/102
C07K 14/285
C12N 9/52
C12N 9/10
C12N 9/16
C12N 9/12
C12N 9/90
C12N 9/02
A61P 37/04
A61P 31/04
C12Q 1/04
US Classification:
4242561, 435 34, 506 18, 506 9, 435 23, 435 74, 530350, 435220, 435193, 435196, 435194, 435233, 435189
Abstract:
A method of identifying a biofilm that includes non-typeable (NTHi) including a step of screening a sample for the presence of one or more biofilm-specific proteins that are expressed by NTHi. In some cases, an NTHi biofilm-related disease in a subject is diagnosed. Also disclosed are protein microarrays for screening biofilm-specific proteins in a sample, formulations comprising one or more biofilm-specific proteins or fragments thereof, and methods for inducing an immune response in a patient against a biofilm-related infection.