Search

Yingjie J Shen

from Columbus, OH
Age ~54
Get Report
Also known as:
Yingjie Y Shen, Yingjie A Shen, Yingjie S Shen, Angie Y Shen, Ying Jie Shen, Angela Y Shen, Ying J Shen, Angelay Y Shen, Yingjie Faeh, Yingjie Shin
Phone and address:
5390 York County Rd, Columbus, OH 43221
Related to:
Pei Y Shen, 66
Connected to:
Albert Shen, 45Ann S Shen, 83Barre W Shen, 33Chiayi Shen, 75Chunfeng Shen, 50Dongmin M Shen, 65En C Shen, 43Erica T Shen, 33Eugenie Shen, 68Fan Shen, 65

Yingjie Shen Phones & Addresses

  • 5390 York County Rd, Columbus, OH 43221
  • Jackson Heights, NY
  • 1925 Commonwealth Ave, Brighton, MA 02135
  • 125 Chiswick Rd, Brighton, MA 02135
  • Roxbury Crossing, MA
  • New York, NY
  • 125 Chiswick Rd APT 314, Brighton, MA 02135

Resumes

Resumes

Yingjie Shen Photo 1

Assistant Professor Of Neuroscience

View page
Location:
Columbus, OH
Industry:
Research
Work:
Harvard Medical School since 2003
Fellow
Dana Farber Cancer Institute 2001 - 2003
Associate
City University of New York 1995 - 2001
Adjunct Lecturer
Education:
City University of New York
The City University of New York
Doctorates, Doctor of Philosophy, Biology Harvard Business School
Skills:
Neuroscience
Drug Discovery
Oncology
Yingjie Shen Photo 2

Yingjie Shen

View page

Publications

Us Patents

Molecular Switch For Neuronal Outgrowth

View page
US Patent:
20140045762, Feb 13, 2014
Filed:
Feb 17, 2012
Appl. No.:
13/985629
Inventors:
John G. Flanagan - Weston MA, US
Yingjie Shen - Brighton MA, US
Edith Yvonne Jones - Oxford, GB
Alexandru Radu Aricescu - Oxford, GB
Charlotte Hannah Bonn - Oxford, DE
Assignee:
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY FO OXFORD - Oxford
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
International Classification:
A61K 31/727
A61K 38/17
US Classification:
514 177, 435375, 514 56
Abstract:
Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase δ (RPTPδ), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTPδ and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTPδ. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTPδ. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.

Neural Regeneration

View page
US Patent:
20120231014, Sep 13, 2012
Filed:
Aug 18, 2010
Appl. No.:
13/391210
Inventors:
John G. Flanagan - Weston MA, US
Alan Peter Tenney - New York NY, US
Yingjie Shen - Brighton MA, US
Jerry Silver - Bay Village OH, US
Assignee:
CASE WESTERN RESERVE UNIVERSITY - Cleveland OH
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
International Classification:
A61K 39/395
A61P 25/00
A61K 38/46
A61K 38/17
C12N 5/0793
C12N 5/071
US Classification:
4241581, 435375, 424 946, 514 177, 4241721
Abstract:
A method of promoting neural cell regeneration is carried out by contacting a neural cell with a compound that inhibits the binding of a chondroitin sulfate proteoglycan (CSPG) to a cellular (e.g., trans-membrane) PTPσ protein. The neural cell is associated with an injury or neurodegenerative condition.
Control profile
Yingjie J Shen from Columbus, OH, age ~54 Get Report