Wenglong Lin Phones & Addresses
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23 Richmond Rd, Newton, MA 02458 (617) 964-3268
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10301 Grosvenor Pl, Rockville, MD 20852 (301) 581-0324
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North Bethesda, MD
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107 Parkcanyon Ln, Cary, NC 27519 (919) 363-1736 (910) 617-9187
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Apex, NC
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Worcester, MA
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Durham, NC
Publications
Us Patents
Feeding Processes For Fermentation
View pageUS Patent:
7521203, Apr 21, 2009
Filed:
May 6, 2005
Appl. No.:
11/123715
Inventors:
WengLong Roy Lin - Rockville MD, US
Firoz Rustom Mistry - Chapel Hill NC, US
Arun Narayanaswamy Tholudur - Longmont CO, US
Edward Todd Sorensen - Raleigh NC, US
Wan-Seop Kim - Morrisville NC, US
Dana Perrin - Cary NC, US
Firoz Rustom Mistry - Chapel Hill NC, US
Arun Narayanaswamy Tholudur - Longmont CO, US
Edward Todd Sorensen - Raleigh NC, US
Wan-Seop Kim - Morrisville NC, US
Dana Perrin - Cary NC, US
Assignee:
N.V. Organon - Oss
International Classification:
G06F 19/00
G01N 33/48
G01N 33/50
C12P 1/00
G01N 33/48
G01N 33/50
C12P 1/00
US Classification:
435 41, 435813, 435818
Abstract:
Embodiments of the present invention generally relate to novel fed-batch fermentations wherein processes of DO-stat and pH-stat are combined for nutrient feeding control.
Novel Feeding Processes For Fermentation
View pageUS Patent:
20040091954, May 13, 2004
Filed:
Nov 12, 2002
Appl. No.:
10/292064
Inventors:
WengLong Lin - Cary NC, US
Firoz Mistry - Chapel Hill NC, US
Arun Tholudur - Cary NC, US
Edward Sorensen - Raleigh NC, US
Wan-Seop Kim - Morrisville NC, US
DANA PERRIN - , US
Firoz Mistry - Chapel Hill NC, US
Arun Tholudur - Cary NC, US
Edward Sorensen - Raleigh NC, US
Wan-Seop Kim - Morrisville NC, US
DANA PERRIN - , US
International Classification:
C12P001/00
US Classification:
435/041000
Abstract:
Embodiments of the present invention generally relate to novel fed-batch fermentations wherein processes of DO-stat and pH-stat are combined for nutrient feeding control.
Cell Culture Apparatus And Methods
View pageUS Patent:
20050221486, Oct 6, 2005
Filed:
Mar 24, 2005
Appl. No.:
11/087801
Inventors:
WengLong Lin - Newton MA, US
Ravinder Bhatia - Blue Bell PA, US
Judith Kadarusman - Catonsville MD, US
John McLaughlin - Doylestown PA, US
Ravinder Bhatia - Blue Bell PA, US
Judith Kadarusman - Catonsville MD, US
John McLaughlin - Doylestown PA, US
Assignee:
Human Genome Sciences, Inc. - Rockville MD
International Classification:
C12N005/02
US Classification:
435404000
Abstract:
A method for culturing cells in a plastic culture vessel is provided. The method is suitable for use when it is desirable to have a small hydrophobic molecule present in the cell culture media at some point during incubation.
Cell Culture Apparatus And Methods
View pageUS Patent:
20070292945, Dec 20, 2007
Filed:
Apr 17, 2007
Appl. No.:
11/736135
Inventors:
Wenglong Lin - Newton MA, US
Ravinder Bhatia - Boyds MD, US
Judith Kadarusman - Savage MD, US
John McLaughlin - Doylestown PA, US
Diana Chinchilla - Boyds MD, US
Jennifer Grason - Rohrersville MD, US
Ravinder Bhatia - Boyds MD, US
Judith Kadarusman - Savage MD, US
John McLaughlin - Doylestown PA, US
Diana Chinchilla - Boyds MD, US
Jennifer Grason - Rohrersville MD, US
International Classification:
C12N 5/02
C12M 3/00
C12M 3/00
US Classification:
435325000, 435289100
Abstract:
A method for culturing cells in a plastic culture vessel is provided. The method is suitable for use when it is desirable to have a small hydrophobic molecule present in the cell culture media at some point during incubation. A plastic cell culture vessel is also provided which is made of a light blocking material capable of blocking exposure of the biological fluid within from light.
Alternating Tangential Flow Rapid Harvesting
View pageUS Patent:
20220325708, Oct 13, 2022
Filed:
Apr 28, 2022
Appl. No.:
17/731295
Inventors:
- Waltham MA, US
WengLong Roy Lin - Newton MA, US
John Bonham-Carter - Somerville MA, US
James R. Rusche - Framingham MA, US
WengLong Roy Lin - Newton MA, US
John Bonham-Carter - Somerville MA, US
James R. Rusche - Framingham MA, US
Assignee:
Repligen Corporation - Waltham MA
International Classification:
F04B 43/06
C07K 1/34
B01D 63/02
C12M 1/00
F04B 53/16
B01D 61/14
B01D 65/08
C12M 1/26
C12N 5/00
C07K 1/34
B01D 63/02
C12M 1/00
F04B 53/16
B01D 61/14
B01D 65/08
C12M 1/26
C12N 5/00
Abstract:
Methods and systems of harvesting a cell product from a cell culture by culturing cells in a fluid medium until the cells have produced a cell product at a harvest concentration are disclosed. The cells are cultured in a cell culture system including a bioreactor connected to an ATF device. The methods include draining fluid medium from the bioreactor through the outlet and the ATF device until the bioreactor volume reaches a predetermined volume, and the ATF column yields at an ATF outlet a liquid containing cell product and passes fluid medium with a concentration of cell product that is lower than the harvest concentration back into the bioreactor, extracting the liquid containing cell product from the ATF outlet, refilling the bioreactor with sterile phosphate buffered saline or fluid medium without any cell product, and repeating steps until a desired amount of cell product has been removed.
Alternating Tangential Flow Rapid Harvesting
View pageUS Patent:
20180148677, May 31, 2018
Filed:
Jul 25, 2017
Appl. No.:
15/659562
Inventors:
- Waltham MA, US
WengLong Roy Lin - Newton MA, US
John Bonham-Carter - Somerville MA, US
James R. Rusche - Framingham MA, US
WengLong Roy Lin - Newton MA, US
John Bonham-Carter - Somerville MA, US
James R. Rusche - Framingham MA, US
International Classification:
C12M 1/26
C12M 1/00
C12N 5/00
C12M 1/00
C12N 5/00
Abstract:
Methods and systems of harvesting a cell product from a cell culture by culturing cells in a fluid medium until the cells have produced a cell product at a harvest concentration are disclosed. The cells are cultured in a cell culture system including a bioreactor connected to an ATF device. The methods include draining fluid medium from the bioreactor through the outlet and the ATF device until the bioreactor volume reaches a predetermined volume, and the ATF column yields at an ATF outlet a liquid containing cell product and passes fluid medium with a concentration of cell product that is lower than the harvest concentration back into the bioreactor, extracting the liquid containing cell product from the ATF outlet, refilling the bioreactor with sterile phosphate buffered saline or fluid medium without any cell product, and repeating steps until a desired amount of cell product has been removed.