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Wayne R Spevak

from Berkeley, CA
Age ~58
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Also known as:
Wayne Dai Shirleko Spevak, Wayne Shirleko Trs Spevak, Wayne Robert Spevak, Wayne E Spevak, Wayne R Spevia, Wayne R Sueva, Wayne K
Phone and address:
1585 Campus Dr, Berkeley, CA 94708
(510) 845-5079
Related to:
Lois A Decker, 99Amelia Blaine, 75Richard Blaine, 87Kevin E Spevak, 32J RichardAmelia E Blaine, 83J Richard Blaine, 88
Connected to:
Elizabeth J Spevak, 43Karen M Spevak, 61Colin C Spewak, 37Thomas A Spewak, 55Christine M Spewock, 47Stanley J Spewock, 54Paul F Spexarth, 93Joseph E Speybroeck, 78April L Speyer, 72Franklin C Speyer, 77

Wayne Spevak Phones & Addresses

  • 1585 Campus Dr, Berkeley, CA 94708 (510) 845-5079
  • 555 Pierce St, Albany, CA 94706 (510) 528-7849
  • Chicago, IL
  • Montgomery, IL
  • Alameda, CA

Work

Company: Plexxikon inc. Aug 2018 Position: Vice president, chemistry

Education

Degree: Doctorates, Doctor of Philosophy School / High School: University of California, Berkeley 1988 to 1993 Specialities: Chemistry

Skills

Drug Discovery • Medicinal Chemistry • Chemistry • Biotechnology • Drug Design • Drug Development • Organic Synthesis • Organic Chemistry • Hplc • Lc Ms • Analytical Chemistry • Nmr • Biochemistry • Lifesciences • Lead Change

Languages

English

Industries

Biotechnology

Resumes

Resumes

Wayne Spevak Photo 1

Vice President, Chemistry

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Location:
Berkeley, CA
Industry:
Biotechnology
Work:
Plexxikon Inc.
Vice President, Chemistry
Plexxikon Inc.
Senior Director of Chemistry
Plexxikon Inc. Mar 2013 - Mar 2016
Director of Chemistry
Plexxikon Inc. Jan 2010 - Mar 2013
Head of Chemistry
Plexxikon Inc. Dec 2004 - Dec 2009
Senior Scientist
Education:
University of California, Berkeley 1988 - 1993
Doctorates, Doctor of Philosophy, Chemistry Northwestern University 1984 - 1988
Bachelors, Bachelor of Arts, Chemistry Proviso West High School
Skills:
Drug Discovery
Medicinal Chemistry
Chemistry
Biotechnology
Drug Design
Drug Development
Organic Synthesis
Organic Chemistry
Hplc
Lc Ms
Analytical Chemistry
Nmr
Biochemistry
Lifesciences
Lead Change
Languages:
English

Publications

Us Patents

Polymeric Assay Film For Direct Colorimetric Detection

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US Patent:
6395561, May 28, 2002
Filed:
Dec 14, 1999
Appl. No.:
09/461509
Inventors:
Deborah Charych - Albany CA
Jon Nagy - Bozeman MT
Wayne Spevak - Albany CA
Assignee:
Regents of the University of California - Oakland CA
International Classification:
G01N 33566
US Classification:
436501, 436528, 436531, 436527, 435 5, 435 71
Abstract:
A lipid bilayer with affinity to an analyte, which directly signals binding by a changes in the light absorption spectra. This novel assay means and method has special applications in the drug development and medical testing fields. Using a spectrometer, the system is easily automated, and a multiple well embodiment allows inexpensive screening and sequential testing. This invention also has applications in industry for feedstock and effluent monitoring.

Naphthalene Ureas As Glucose Uptake Enhancers

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US Patent:
6458998, Oct 1, 2002
Filed:
May 25, 2000
Appl. No.:
09/579279
Inventors:
Wayne R. Spevak - Albany CA
Songyuan Shi - Fremont CA
Prasad V. V. S. V. Manchem - South San Francisco CA
Michael R. Kozlowski - Palo Alto CA
Steven R. Schow - Redwood Shores CA
Robert T. Lum - Palo Alto CA
Assignee:
Telik, Inc. - South San Francisco CA
International Classification:
C07C27300
US Classification:
564 55, 564 48, 564 49, 564 50, 564 52, 514596, 435 14
Abstract:
Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake of glucose. Pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.

Substituted Stilbenes As Glucose Uptake Enhancers

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US Patent:
6479548, Nov 12, 2002
Filed:
May 31, 2001
Appl. No.:
09/872763
Inventors:
John Patterson - Mountain View CA
Sophia Park - Emeryville CA
Robert T. Lum - Palo Alto CA
Wayne R. Spevak - Albany CA
Assignee:
Telik, Inc. - South San Francisco CA
International Classification:
A61K 31195
US Classification:
514567, 514534, 514538, 514562, 514564, 560 19, 562457
Abstract:
Compound of formula I activate the insulin receptor kinase. Pharmaceutical compositions comprising the compounds, and methods of treatment of hyperglycemia and other diseases involving imbalance of glucose levels, especially for the treatment of type II diabetes, by administering these compounds to mammalian hosts, and processes for their preparation, are also described.

Naphthylsulfonic Acids And Related Compounds As Glucose Uptake Agonists

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US Patent:
6653321, Nov 25, 2003
Filed:
Jul 28, 2000
Appl. No.:
09/628206
Inventors:
Wayne R. Spevak - Albany CA
Songyuan Shi - Fremont CA
Prasad V. V. S. V. Manchem - South San Francisco CA
Michael R. Kozlowski - Palo Alto CA
Steven R. Schow - Redwood Shores CA
Robert T. Lum - Palo Alto CA
Louise Robinson - San Carlos CA
Jeong Weon Park - Emeryville CA
Assignee:
Telik, Inc. - Palo Alto CA
International Classification:
A61K 3150
US Classification:
514307, 514256, 514311, 514315, 514319, 514332, 514357, 514365, 514374, 514385, 514415, 514428, 514438, 514447, 514451, 514459, 514461, 514471, 514521, 514503, 514568, 514576, 514613, 514615, 514619, 514620, 544238, 544239, 544240, 544241, 544242, 544333, 544334, 544335, 544336, 546139, 546146, 546149, 546152, 546157, 546162, 546174, 546175, 546192, 546195, 546205, 546206, 546246, 546247, 546248, 548146, 548215, 548233, 5483001, 5483265, 5483481, 5483491, 5483501, 548469, 548566, 549139, 549146, 549149, 549152, 549157, 549162, 549174, 549175, 549192, 549195, 549205, 549206, 549246, 549247, 549248, 558 17, 562 54, 564162, 564163, 564165, 564169, 564180, 564185
Abstract:
Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or mixtures of stereoisomers, or their pharmaceutically acceptable salts, are useful in methods of stimulating the kinase activity of the insulin receptor, enhancing the activation of the insulin receptor by insulin, and stimulating the uptake of glucose into cells. A variety of antidiabetic compounds and pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.

Nonpeptide Insulin Receptor Agonists

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US Patent:
RE38915, Dec 6, 2005
Filed:
Dec 21, 2000
Appl. No.:
09/748665
Inventors:
Richard Sportsman - Palo Alto CA, US
Hugo O. Villar - Newark CA, US
Lawrence M. Kauvar - San Francisco CA, US
Wayne R. Spevak - Albany CA, US
Assignee:
Telik, Inc. - Palo Alto CA
International Classification:
A61K031/05
A61K031/10
A61K031/17
A61K031/655
US Classification:
514 4, 514150, 514477, 514483, 514562, 514563, 514596, 514597, 514598, 514617, 514618, 514619, 514616, 514708, 514762, 514866
Abstract:
Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula wherein.

Naphthalene Ureas As Glucose Uptake Enhancers

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US Patent:
7071231, Jul 4, 2006
Filed:
Sep 6, 2002
Appl. No.:
10/237583
Inventors:
Wayne R. Spevak - Albany CA, US
Songyuan Shi - Fremont CA, US
Prasad V. V. S. V. Manchem - South San Francisco CA, US
Michael R. Kozlowski - Palo Alto CA, US
Steven R. Schow - Redwood Shores CA, US
Robert T. Lum - Palo Alto CA, US
Assignee:
Telik, Inc. - Palo Alto CA
International Classification:
A61K 31/18
C12N 5/06
C07C 309/01
US Classification:
514595, 435334, 564 49
Abstract:
Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake of glucose. Pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.

Nonpeptide Insulin Receptor Agonists

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US Patent:
RE39866, Oct 2, 2007
Filed:
Jun 23, 2005
Appl. No.:
11/167026
Inventors:
Richard Sportsman - Encinitas CA, US
Hugo O. Villar - La Jolla CA, US
Lawrence M Kauvar - San Francisco CA, US
Wayne R Spevak - Berkeley CA, US
Assignee:
Telik, Inc. - San Francisco CA
International Classification:
A61K 31/655
A61K 31/17
A61K 31/10
A61K 31/015
C07C 245/00
US Classification:
514150, 514596, 514597, 514598, 514708, 514765, 514866, 534573, 534806, 534808
Abstract:
Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula whereinCompounds in the genus of Formula (1) can also be used for structure activity studies to identify features responsible for the relevant activities.

Compounds Modulating C-Kit And C-Fms Activity And Uses Therefor

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US Patent:
7846941, Dec 7, 2010
Filed:
May 16, 2006
Appl. No.:
11/435381
Inventors:
Chao Zhang - Moraga CA, US
Jiazhong Zhang - Oakland CA, US
Prabha N. Ibrahim - Mountain View CA, US
Clarence R. Hurt - San Ramon CA, US
Rebecca Zuckerman - Alameda CA, US
Dean R. Artis - Kensington CA, US
Ryan Bremer - Emeryville CA, US
Wayne Spevak - Berkeley CA, US
Guoxian Wu - Palo Alto CA, US
Hongyao Zhu - Berkeley CA, US
Assignee:
Plexxikon, Inc. - Berkeley CA
International Classification:
A61K 31/437
C07D 471/04
US Classification:
514300, 546113, 544127, 5142345
Abstract:
Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
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Wayne R Spevak from Berkeley, CA, age ~58 Get Report