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Venkatraman Radhika Mohan

from Carlsbad, CA
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Also known as:
Mohan Venkatraman
Phone and address:
7042 Via Cabana, Carlsbad, CA 92009
(760) 431-9655
Related to:
Bharat Mohan, 35Radhika Mohan, 60Mohan Venkatraman, 64
Connected to:
Aashish Mohan, 42Aditya S Mohan, 56Anirudh Mohan, 32Arathi Mohan, 36Bernadette M Mohan, 90Bernie M Mohan, 58Beverly A Mohan, 77Bhavana H Mohan, 50Bhuma Mohan, 66

Venkatraman Mohan Phones & Addresses

  • 7042 Via Cabana, Carlsbad, CA 92009 (760) 431-9655
  • Muskegon, MI
  • 1 Barn Swallow Ct, Plainsboro, NJ 08536 (609) 897-7960
  • 10 Sycamore Dr, Plainsboro, NJ 08536 (609) 897-7960
  • Grand Haven, MI
  • Houston, TX

Skills

Clinical Development • Oncology • Product Development • Business Development • Biopharmaceuticals • Project Management • Six Sigma • Leadership • Patents • Drug Design • Science • Mergers and Acquisitions • Negotiation • Lead Generation • Marketing Management • Fda • Pharmaceutics • Gmp • Chemistry • Process Simulation

Languages

English

Industries

Biotechnology

Resumes

Resumes

Venkatraman Mohan Photo 1

Venkatraman Mohan

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Location:
6980 Sandcastle Dr, Carlsbad, CA 92011
Industry:
Biotechnology
Skills:
Clinical Development
Oncology
Product Development
Business Development
Biopharmaceuticals
Project Management
Six Sigma
Leadership
Patents
Drug Design
Science
Mergers and Acquisitions
Negotiation
Lead Generation
Marketing Management
Fda
Pharmaceutics
Gmp
Chemistry
Process Simulation
Languages:
English

Publications

Us Patents

Oligonucleotides Having A-Dna Form And B-Dna Form Conformational Geometry

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US Patent:
6369209, Apr 9, 2002
Filed:
May 3, 1999
Appl. No.:
09/303586
Inventors:
Muthiah Manoharan - Carlsbad CA
Venkatraman Mohan - Carlsbad CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 2100
US Classification:
536 231, 536 245
Abstract:
Modified oligonucleotides containing both A-form conformation geometry and B-from conformation geometry nucleotides are disclosed. The B-form geometry allows the oligonucleotide to serve as substrates for RNase H when bound to a target nucleic acid strand. The A-form geometry imparts properties to the oligonucleotide that modulate binding affinity and nuclease resistance. By utilizing C2â endo sugars or O4â endo sugars, the B-form characteristics are imparted to a portion of the oligonucleotide. The A-form characteristics are imparted via use of either 2â-O-modified nucleotides that have 3â endo geometries or use of end caps having particular nuclease stability or by use of both of these in conjunction with each other.

Guanidinium Functionalized Oligonucleotides And Method/Synthesis

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US Patent:
6534639, Mar 18, 2003
Filed:
Jul 7, 2000
Appl. No.:
09/612531
Inventors:
Muthiah Manoharan - Carlsbad CA
Phillip Dan Cook - Fallbrook CA
Thazha P. Prakash - Carlsbad CA
Venkatraman Mohan - Carlsbad CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 2100
US Classification:
536 231, 536 243, 536 245, 536 2534
Abstract:
The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.

Antimicrobial 2-Deoxystreptamine Compounds

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US Patent:
6541456, Apr 1, 2003
Filed:
Dec 1, 1999
Appl. No.:
09/452606
Inventors:
Eric Swayze - Carlsbad CA
Richard H. Griffey - Vista CA
Yili Ding - San Diego CA
Venkatraman Mohan - Carlsbad CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
A61K 317036
US Classification:
514 38, 514 36, 514 42, 514 53, 514 40, 536 132, 536 133, 536 166, 536 168
Abstract:
The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention comprises at least one aryl, heteroaryl, substituted aryl or substituted heteroaryl group in place of a glycosyl group attached to the 2-deoxystreptamine ring.

Guanidinium Functionalized Nucleotides And Precursors Thereof

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US Patent:
6593466, Jul 15, 2003
Filed:
Jul 7, 1999
Appl. No.:
09/349040
Inventors:
Muthiah Manoharan - Carlsbad CA
Phillip Dan Cook - Fallbrook CA
Thazha P. Prakash - Carlsbad CA
Venkatraman Mohan - Carlsbad CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 1904
US Classification:
536 267, 536 268, 536 276, 536 2781, 536 285, 536 2853
Abstract:
The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.

Oligonucleotides Having A-Dna Form And B-Dna Form Conformational Geometry

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US Patent:
6737520, May 18, 2004
Filed:
Mar 15, 2002
Appl. No.:
10/098816
Inventors:
Muthiah Manoharan - Carlsbad CA
Venkatraman Mohan - Carlsbad CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 2102
US Classification:
536 231, 536 245
Abstract:
Modified oligonucleotides containing both A-form conformation geometry and B-from conformation geometry nucleotides are disclosed. The B-form geometry allows the oligonucleotide to serve as substrates for RNase H when bound to a target nucleic acid strand. The A-form geometry imparts properties to the oligonucleotide that modulate binding affinity and nuclease resistance. By utilizing C2â endo sugars or O4â endo sugars, the B-form characteristics are imparted to a portion of the oligonucleotide. The A-form characteristics are imparted via use of either 2â-O-modified nucleotides that have 3â endo geometries or use of end caps having particular nuclease stability or by use of both of these in conjunction with each other.

Antimicrobial 2-Deoxystreptamine Compounds

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US Patent:
6759523, Jul 6, 2004
Filed:
Nov 30, 2000
Appl. No.:
09/727315
Inventors:
Eric Swayze - Carlsbad CA
Richard H. Griffey - Vista CA
Yili Ding - San Diego CA
Venkatraman Mohan - Carlsbad CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 1522
US Classification:
536 132, 536 133, 536 166, 536 168, 536 179
Abstract:
The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention comprises at least one aryl, heteroaryl, substituted aryl or substituted heteroaryl group in place of a glycosyl group attached to the 2-deoxystreptamine ring.

Optimization Of Ligand Affinity For Rna Targets Using Mass Spectrometry

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US Patent:
6770486, Aug 3, 2004
Filed:
Feb 8, 2000
Appl. No.:
09/499875
Inventors:
Richard Griffey - Vista CA
Steven Hofstadler - Oceanside CA
Jared J. Drader - Encinitas CA
Kristin S. Lowery - Vista CA
Venkatraman Mohan - Carlsbad CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
G01N 2400
US Classification:
436173, 435 6, 435 71, 435 912
Abstract:
The present invention provides methods for the identification ligand compounds that bind to target molecules such as proteins or structured RNA with as little as millimolar (mM) affinity using mass spectrometry. The methods may be used to determine the mode of binding interaction between two or more of these ligand compounds to the target as well as their relative affinities. Also provided are methods for designing compounds having greater affinity to a target molecule by identifying two or more ligands using mass spectrometry methods of the invention and linking the ligands together to form a novel compound.

Guanidinium Functionalized Intermediates

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US Patent:
6914148, Jul 5, 2005
Filed:
Sep 20, 2002
Appl. No.:
10/247893
Inventors:
Muthiah Manoharan - Carlsbad CA, US
Phillip Dan Cook - Fallbrook CA, US
Thazha P. Prakash - Carlsbad CA, US
Venkatraman Mohan - Carlsbad CA, US
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07F009/02
US Classification:
558 70, 536 231, 536 243, 536 245, 536 267, 536 268
Abstract:
The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.
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Venkatraman Radhika Mohan from Carlsbad, CA Get Report