Venkatram R Shastri

6355224, Mar 12, 2002

Sep 17, 1998

09/156549

Venkatram R. Shastri - Allston MA

Massachusetts Institute of Technology - Cambridge MA

A61B 5055

424 93, 424 9322

The use of electroactive materials having regions of high electron density as contrast agents in magnetic resonance imaging is described. The electroactive materials may be electroactive polymers, inorganic clusters, carbon clusters, molecules that inherently exhibit electron donor-acceptor behavior having regions or moieties of high electron density, or any combination of the abovementioned contrast agents. The contrast agents of the invention decrease relaxation times of water when introduced into a subject for magnetic resonance imaging. It is particularly preferred that the contrast agents be introduced in the form of a colloidal suspension.

6471993, Oct 29, 2002

Jan 28, 2000

09/463709

Venkatram R. Shastri - Allston MA
Ivan Martin - Somerville MA
Robert S. Langer - Newton MA
Joachim Seidel - Somerville MA

Massachusetts Institute of Technology - Cambridge MA

A61K 914

424486, 424484, 424487, 424422, 424423, 424424, 424425, 424426, 5147723

Matrices that include a macrostructure having a semi-solid network and voids, and a microstructure having voids, in which the microstructure is located within the semi-solid network are disclosed. Methods for preparing these matrices are also disclosed.

6569654, May 27, 2003

Jan 2, 2001

09/753407

Venkatram Shastri - Lower Gwynedd PA
Ivan Martin - Oberwil, CH
Robert Langer - Newton MA
Nahid Rahman - Boston MA

Massachusetts Institute of Technology - Cambridge MA

C12N 1300

4351738

Compositions, methods and systems are provided for the stimulation of biological activities within stem cells by applying electromagnetic stimulation to an electroactive material, wherein the electromagnetic stimulation is coupled to the electromagnetic material. In general the present invention involves attaching or associating the desired cells to or with a surface comprising an electroactive material, and applying electromagnetic radiation directly to the desired area. In preferred embodiments, the stimulation of biological activities within cells results from inducing one or more activities including, but not limited to, gene expression, cell growth, cell differentiation, signal transduction, membrane permeability, cell division, contraction, and cell signaling. In exemplary embodiments, the electroactive materials used in the present invention are either two-dimensional substrates such as thin films having at least one surface of an electroactive material, or in alternative embodiments, the electroactive materials are three-dimensional substrates comprising a matrix having at least one surface of an electroactive material.

6582717, Jun 24, 2003

Apr 7, 2000

09/543964

Venkatram R. Shastri - Randolph MA
Isaac Yue - Boston MA
Robert S. Langer - Newton MA

Massachusetts Institute of Technology - Cambridge MA

A61F 200

424426, 424423, 424486

Drug delivery composition. The composition includes a polymeric material, a complexing agent, and a bioactive agent complexed with the complexing agent. The polymeric material, the complexing agent and the bioactive agent are formed into a delivery matrix. The delivery matrix is particularly adapted for placement below the gum line in a periodontal cavity.

6699505, Mar 2, 2004

Oct 17, 2001

09/981655

Venkatram R. Shastri - Lower Gwynedd PA
Isaac Yue - Midland MI
Patrice Hildgen - Laval, CA
Ruben Dario Sinisterra - Belo Horizonte, BR
Robert Langer - Newton MA

Massachusetts Institute of Technology - Cambridge MA

A61K 914

424486, 424484, 424488, 424422, 424426, 514 54, 514 58

The present invention provides methods of increasing the biological activity of a bioactive agent by complexing the bioactive agent with a complexing agent. In one preferred embodiment, the bioactive agent is an antibiotic and the complexing agent is a cyclodextrin. However, the invention may be extended to include any drugs as bioactive agents. In certain preferred embodiments, the bioactive agent fits into a hydrophobic core of a complexing agent.

6730772, May 4, 2004

Jun 22, 2001

09/886394

Venkatram P. Shastri - Ambler PA, 19002

C08G 6308

528354, 528357, 528370, 528409, 528421

A polymer of a ring-opened functionalized epoxide is formed by the polymerization of a functionalized epoxide monomer having the structure E-CHR-G wherein E represents an epoxide group, R is hydrogen or an alkyl group, and G is a derivatizable group such as an unsaturated functionality or ester substituent.

7108721, Sep 19, 2006

May 10, 2001

10/275618

James William Huckle - Northallerton, GB
Melissa Anderson - Hull, GB
Allen E. Goodship - Herts, GB
Venkatram R. Shastri - Lower Gwynedd PA, US

Massachusetts Institute of Technology - Cambridge MA

A61F 2/36
A61F 2/08
A61F 2/28

623 2374, 623 2376

The present invention is based on the discovery of new methods for obtaining a tissue graft. The method can be carried out, for example, by implanting a biocompatible scaffold into a mammal and then removing the scaffold from the mammal. The scaffold is implanted in direct contact with (i. e. physically touching over at least a portion of its external surface), or adjacent to (i. e. physically separated from) mature or immature target tissue, for a period of time that is sufficient to allow cells of the target tissue to associate with the scaffold. The invention also features grafts generated by the methods described herein and methods for using those grafts to treat patients who have a defect in a target.

7291693, Nov 6, 2007

Jun 25, 2002

10/180000

Venkatram Prasad Shastri - Lower Gwynedd PA, US
Alexander Zelikin - Moscow, RU
David Lynn - Middleton WI, US
Robert S. Langer - Newton MA, US
Ivan Martin - Oberwil, CH

Massachusetts Institute of Technology - Cambridge MA

C08G 73/06

528423, 528424, 528271, 528287, 528293

The present invention specifically contemplates a polymer, preferably an electrically conductive polymer, derived from substituted pyrrolyl moieties.