Inventors:
Brian J. Carroll - Gig Harbor WA, US
Gary Darland - Gig Harbor WA, US
Anuradha Desai - Gig Harbor WA, US
Veera Konda - Gig Harbor WA, US
Clinton J. Dahlberg - Port Orchard WA, US
Jan Urban - Gig Harbor WA, US
Assignee:
KinDex Therapeutics, LLC - Seattle WA
International Classification:
A61K 31/12
C07C 49/00
Abstract:
The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (−)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, activate GPR120, inhibit inflammation, and treat conditions responsive to PPARγ modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes.