Urs Otto Hafeli

6413271, Jul 2, 2002

Jan 11, 2000

09/481247

Urs Hafeli - Cleveland OH
Uziel Landau - Shaker Heights OH
Matt C. Warburton - Strongsville OH

The Cleveland Clinic Foundation - Cleveland OH
Case Western Reserve University - Cleveland OH

A61F 206

623 115, 623 144, 623 146

The present invention provides a method for preparing an implantable, medical device having at least one radioactive metallic surface. The method comprises the steps of depositing a radioactive metal layer onto the surface of the device. The metal layer comprises a radioactive metal that emits beta particles and that has a half-life of between 2 hours and 7 days and a maximum beta energy of between 0. 7 and 2. 3 MeV. In one embodiment, the radioactive layer is deposited by electroplating the radioactive metal and a carrier metal onto the metallic surface. In another embodiment, the method further comprises the step of electroplating a second metallic layer comprising a barrier metal onto the radioactive metal layer. The present invention also provides an implantable medical device comprising a surface having a metallic surface comprising a radioactive metallic coating thereon. The coating comprises a radioactive layer comprising a radioactive metal that emits beta-particles.

6494835, Dec 17, 2002

Feb 16, 2000

09/505388

Jay P. Ciezki - Shaker Heights OH
Urs Hafeli - Cleveland OH
David Bleam - Orangevale CA

Jomed Inc. - Rancho Cordova CA
Cleveland Clinic Foundation - Cleveland OH

A61B 800

600439

A method for providing intravascular brachytherapy includes the step of positioning a radiation source within a target area to be radiation and orienting the attenuator found on the catheter. Once the attenuator or shield is properly oriented, a reference or normalization point or marker ( ) is selected. This reference marker ( ) can placed, as one example, on the external elastic lamina closest to catheter ( ) and can serve as a reference point for the brachytherapy treatment. Several other points of interest can be is selected ( ) on the image ( ) or images that have been gathered of the treatment site, with dosage levels ( and ) being display automatically on the display ( ) close to the IVUS image ( ).

20030120355, Jun 26, 2003

Jun 10, 2002

10/166449

Urs Hafeli - Cleveland OH, US
Sandra Rudershausen - Rostock, DE
Joachim Teller - Rostock, DE
Cordula Gruttner - Rostock, DE

G05B015/00

700/001000

This invention relates to biocompatible and biodegradable polymers which are able to bind diagnostic and therapeutic radioisotopes, and the therapeutic use of the same as well as the synthesis of such polymers. It further relates to the preparation of functional implants from these materials, including nanospheres, microspheres, liposomes, micelles, coatings, films, fibers, and foils.

60774134, Jun 20, 2000

Feb 6, 1998

9/019908

Urs Hafeli - Cleveland OH
Uziel Landau - Shaker Heights OH
Matt C. Warburton - Strongsville OH

The Cleveland Clinic Foundation - Cleveland OH
Case Western Reserve University - Cleveland OH

C25D 510
C23C 2802
C23C 2800
A61M 3614
A61L 5103

205170

A method for preparing a radioactive, implantable, medical device is provided. The method involves depositing a layer of a radioactive metal that emits beta particles and that has a half-life of between 2 hours and 7 days and a maximum beta energy of between 0. 7 and 2. 3 MeV onto a metallic surface of the device. In one embodiment, the radioactive metal and a carrier metal are electroplated onto the metallic surface. In another embodiment, a second metallic layer comprising a barrier metal is electroplated onto the radioactive metal layer. A medical device having a metallic surface with a radioactive metallic coating thereon is provided. In one embodiment, the coating comprises a radioactive layer comprising a radioactive metal that emits beta-particles and that has a half-life of between 2 hours and 7 days and an energy level of from about 0. 7 MeV to 2. 3 MeV and a carrier metal.

60246901, Feb 15, 2000

Jul 1, 1997

8/886602

Eric J. Lee - Pepper Pike OH
Urs Hafeli - Cleveland OH
Eugene J. Jung - San Diego CA

Endosonics Corporation - Rancho Cordova CA

A61N 500

600 3

A radiation source for delivering a dose of radiation to a treatment site of a vessel is provided herein. The radiation source includes a delivery wire and a radioactive segment. The radioactive segment includes a substantially coiled or entwined radioactive wire which allows the radioactive segment to have a relatively large surface area to volume ratio. The delivery wire is made of material having a relatively short half-life, such as titanium, while the radioactive segment is made of a material, such as a rhenium or yttrium, which has a much longer half-life.