Udo Hoss

6852500, Feb 8, 2005

Jul 20, 2000

09/620038

Udo Hoss - Sherman Oaks CA, US
Hans-Joerg Pfleiderer - Ulm, DE
Ralf Gessler - Baienfurt, DE
Hans-Ulrich Zieten - Illerrieden, DE
Rolf Fussgaenger - Blaustein-Weldach, DE

Roche Diagnostics GmbH - Mannheim

C12Q001/54

435 14, 600315, 600317, 600365

The invention concerns a method and an arrangement for determining the concentration of glucose in a body fluid. In the microdialysis technology used for this purpose, perfusate containing glucose is transported in intermittent delivery pulses through a microdialysis probe () inserted into the body fluid and dialysate obtained in this process is passed to a measuring cell () to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the body fluid by means of a control device () in accordance with a command variable derived from the measurement signals of the measuring cell (). When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the body fluid.

6925393, Aug 2, 2005

Nov 13, 2000

09/711855

Brit Kalatz - Ulm, DE
Udo Hoss - Sherman Oaks CA, US

Roche Diagnostics GmbH - Mannheim

G06F019/00
G01N033/48
G01N031/00

702 27, 702 19, 702 22

A system for the extrapolation of a glucose concentration has a data input device for entering administered insulin doses and their times of administration, a data input device for entering the carbohydrates consumed or to be consumed, a unit for determining an actual glucose concentration at a point in time (t) in a patient's bodily fluid, a memory unit, and an evaluation unit for evaluation of the data stored in the memory unit, and for the extrapolation of a glucose concentration at a point in time t, whereby tis after tThe extrapolation includes determining the portion (I) of insulin doses that become effective between tand t; determining the portion of consumed carbohydrate units KH, that become effective between tand t; and determining an extrapolated glucose concentration Gat the point in time twith consideration for Iand KH.

7169600, Jan 30, 2007

Feb 19, 2004

10/782290

Udo Hoss - Sherman Oaks CA, US
Hans-Joerg Pfleiderer - Ulm, DE
Ralf Gessler - Baienfurt, DE
Hans-Ulrich Zieten - Illerrieden, DE
Rolf Fussgaenger - Blaustein-Weidach, DE

Roche Diagnostics GmbH - Mannheim

C12M 1/34

4352871, 435 14

The invention concerns an arrangement for determining the concentration of glucose in a tissue fluid. In the microdialysis technology used for this purpose, perfusate-containing glucose is transported in intermittent delivery pulses through a microdialysis probe inserted into the tissue fluid and dialysate obtained in this process is passed to a measuring cell to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the tissue fluid by means of a control device in accordance with a command variable derived from the measurement signals of the measuring cell. When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the tissue fluid.

7468033, Dec 23, 2008

Sep 8, 2004

10/935954

Nannette M. Van Antwerp - Valencia CA, US
Bradley J. Enegren - Moorpark CA, US
John J. Mastrototaro - Los Angeles CA, US
Rajiv Shah - Palos Verdes CA, US
Udo Hoss - Sherman Oaks CA, US
Yanan Zhang - Valencia CA, US
Kent L. Clark - La Crescenta CA, US

Medtronic MiniMed, Inc. - Northridge CA

A61B 5/00
A61M 37/00

600309, 600300, 600364, 600365, 604 401

The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

7813780, Oct 12, 2010

Dec 13, 2005

11/301512

Rajiv Shah - Palos Verdes CA, US
Gopikrishnan Soundararajan - Los Angeles CA, US
Rebecca K. Gottlieb - Culver City CA, US
Udo Hoss - Sherman Oaks CA, US
Eric A. Grovender - Santa Monica CA, US
Shaun M. Pendo - Wofford Heights CA, US

Medtronic MiniMed, Inc. - Northridge CA

A61B 5/05

600345, 600365, 600348, 20440301, 20440306, 20440307, 20440309

Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.

7822455, Oct 26, 2010

Jul 31, 2009

12/533742

Udo Hoss - Castro Valley CA, US
Zenghe Liu - Alameda CA, US
Benjamin Jay Feldman - Oakland CA, US

Abbott Diabetes Care Inc. - Alameda CA

A61B 5/1473
A61B 5/05

600347, 600365, 600345, 20440301, 20440314

An analyte sensor system including a substrate, a first electrode disposed on a first surface of the substrate, a second electrode disposed on a second surface of the substrate, a third electrode provided in electrical contact with at least one of the first or second electrodes, where at least a portion of the first electrode and the second electrode are subcutaneously positioned in a patient, and where the third electrode is substantially entirely positioned external to the patient, and corresponding methods are provided.

7826879, Nov 2, 2010

Feb 28, 2006

11/365169

Udo Hoss - Alameda CA, US
Zenghe Liu - Alameda CA, US
Benjamin J. Feldman - Oakland CA, US

Abbott Diabetes Care Inc. - Alameda CA

A61B 5/05
A61B 5/1473

600347, 600345, 600365, 20440301, 20440314

An analyte sensor system including a substrate, a first electrode disposed on a first surface of the substrate, a second electrode disposed on a second surface of the substrate, a third electrode provided in electrical contact with at least one of the first or second electrodes, where at least a portion of the first electrode and the second electrode are subcutaneously positioned in a patient, and where the third electrode is substantially entirely positioned external to the patient, and corresponding methods are provided.

8000763, Aug 16, 2011

Jun 30, 2009

12/495696

John C. Mazza - Pleasanton CA, US
Songbiao Zhang - Fremont CA, US
Udo Hoss - Castro Valley CA, US
Christopher Thomas - San Leandro CA, US

Abbott Diabetes Care Inc. - Alameda CA

A61B 5/05

600347, 600345

The present disclosure provides electrode structures and integrated electrode structures having one or more conductive materials coextruded with one or more dielectric materials. The disclosed electrode structures can be configured for use as analyte sensors. Also provided, are methods of making and using the electrode structures and integrated electrode structures described herein.