US Patent:
20050203007, Sep 15, 2005
Inventors:
Tomoko Komiyama - Ann Arbor MI, US
Robert Fuller - Ann Arbor MI, US
International Classification:
A61K038/54
Abstract:
The present invention relates to eglin c variants which inhibit proteases, and in particular to eglin c mutants at adventitious contact sites. The present invention also relates to eglin c variants which comprise mutations in both adventitious contact sites and at reactive loop sites. The present invention further relates to methods of preparing the eglin c variants, and methods of using the eglin c variants for treatment of diseases including acute bacterial, viral, and fungal infections.