Timothy W Starzl

20010029050, Oct 11, 2001

Jun 14, 2001

09/882396

Timothy Starzl - Boulder CO, US
David Nunnery - Westminster CO, US
MaryBeth Robinson - Boulder CO, US
H. Hanlin - Louisville CO, US

Accelr8 Technology Corporation

G01N033/543

436/518000

A system for detecting a specific substance or analyte of interest is provided that includes one or more sensing units and an instrument for analyzing the sensing units. Each sensing unit preferably includes a substrate, an attachment layer and at least one capture layer that includes a ligand layer. In one embodiment, the attachment layer is tripartite and includes a lower binding surface held to the substrate and an upper binding surface that holds the ligand layer, together with an insulating layer disposed between these two surfaces. The lower binding surface provides a durable and stable attachment to the substrate. The upper binding surface holds the ligand layer and does not jeopardize the integrity or viability thereof. The insulating layer prevents any unwanted interaction between the lower and upper binding surfaces. Each sensing unit is supported on a test piece received by the instrument. The instrument controllably positions the test piece using marks and/or codes on the test piece. The instrument measures a difference in mass in the sensing unit in connection with determining whether or not the analyte of interest is present. A light beam is used in making this measurement. In one embodiment, multiple reflections of the light beam on the same sensing unit are utilized to improve the sensitivity of the instrument. Mass enhancement techniques are also preferably utilized to effectively amplify the detected signal that is indicative of the analyte's presence. The system can also include a device for heating, humidifying and mixing materials of the sensing units, as well as preventing cross-contamination of the sensing units.

20020103809, Aug 1, 2002

Feb 2, 2001

09/776161

Timothy Starzl - Boulder CO, US
Ravi Starzl - Boulder CO, US

SearchLogic.com Corporation

G06F007/00

707/102000

An automated system and method for creating a topical data structure of documents or other items from an inter-linked system of documents, such as the Web and/or the Internet. The data structure can then be searched using conventional means information to generate highly relevant results. The system automatically utilizes pre-existing search resources to discover and collect topically relevant information from the inter-linked system of documents, which can be added to the topical data structure. The topically relevant information collected using the pre-existing search resources can be directly added to the data structure or can be further filtered for relevancy before being added to the data structure.

20030153023, Aug 14, 2003

Feb 25, 2002

10/084632

Timothy Starzl - Boulder CO, US
Scott Clark - Denver CO, US
Mary Vellequette - Louisville CO, US
H. Hanlin - Louisville CO, US
Steven Metzger - Fort Collins CO, US

G01N033/53
G01N033/537
G01N033/543
G06F019/00
G06K009/00

435/007920, 382/128000, 702/019000

This invention is directed to an optically-based method and system for analyte detection using solid phase immobilization, specific analyte labels adapted for signal generation and corresponding processes for the utilization thereof. The enumeration detection method disclosed herein narrows the area for signal observation, thus, improving detectable signal to background ratio. The system is comprised of a platform/support for immobilizing a sample stage having a labeled sample (analyte complex) bound thereto, a radiation source, an optical apparatus for generating and directing radiation at said sample and a control that obtains data and then conducts analyses using digital image data. Upon engagement of the system, the sample generates a signal capable of differentiation from background signal, both of which are collected and imaged with a signal detector that generated a sample image to a data processing apparatus. This apparatus receives signal measurements and, in turn, enumerates individual binding events. Generated signal may be increased via selected mass enhancement. The invention, enumeration assay methodology detecting individual binding events, may be used, for example, in analyses to detect analyte or confirm results in both research, commercial and point of care applications.

20070298513, Dec 27, 2007

Oct 23, 2006

11/552111

Timothy Starzl - Boulder CO, US
Scott Clark - Denver CO, US
Mary Vellequette - Louisville CO, US
H. Hanlin - Louisville CO, US
Steven Metzger - Fort Collins CO, US

Accelr8 Technology Corporation - Denver CO

G01N 21/01

436164000

This invention is directed to an optically-based method and system for analyte detection using solid phase immobilization, specific analyte labels adapted for signal generation and corresponding processes for the utilization thereof. The enumeration detection method disclosed herein narrows the area for signal observation, thus, improving detectable signal to background ratio. The system is comprised of a platform/support for immobilizing a sample stage having a labeled sample (analyte complex) bound thereto, a radiation source, an optical apparatus for generating and directing radiation at said sample and a control that obtains data and then conducts analyses using digital image data. Upon engagement of the system, the sample generates a signal capable of differentiation from background signal, both of which are collected and imaged with a signal detector that generated a sample image to a data processing apparatus. This apparatus receives signal measurements and, in turn, enumerates individual binding events. Generated signal may be increased via selected mass enhancement. The invention, enumeration assay methodology detecting individual binding events, may be used, for example, in analyses to detect analyte or confirm results in both research, commercial and point of care applications.

20120141458, Jun 7, 2012

Nov 22, 2011

13/302836

Timothy W. Starzl - Boulder CO, US

PANTHERYX, INC. - Boulder CO

A61K 39/395
A61P 31/04
A61P 31/22
A61P 1/00
A61P 31/16
A61P 1/12
A61P 1/04
A61P 29/00
A61P 31/00
A61P 31/10

4241301

The disclosure provides improved compositions and methods for passive immunization. In embodiments, a composition comprising a synergistic combination of specific polyclonal antibodies in a carrier matrix is provided. The disclosure provides effective, economical compositions and methods for the treatment of diarrhea and enteric infections in broad-spectrum, undifferentiated, or mixed clinical applications.

62743848, Aug 14, 2001

Jul 6, 1999

9/346039

Timothy W. Starzl - Boulder CO
David W. Nunnery - Westminster CO
MaryBeth Robinson - Boulder CO
H. John Hanlin - Louisville CO

Accelr8 Technology Corporation - Denver CO

G01N 33543

436518

A system for detecting a specific substance or analyte of interest is provided that includes one or more sensing units and an instrument for analyzing the sensing units. Each sensing unit preferably includes a substrate, an attachment layer and at least one capture layer that includes a ligand layer. In one embodiment, the attachment layer is tripartite and includes a lower binding surface held to the substrate and an upper binding surface that holds the ligand layer, together with an insulating layer disposed between these two surfaces. The lower binding surface provides a durable and stable attachment to the substrate. The upper binding surface holds the ligand layer and does not jeopardize the integrity or viability thereof. The insulating layer prevents any unwanted interaction between the lower and upper binding surfaces. Each sensing unit is supported on a test piece received by the instrument.

55424317, Aug 6, 1996

Dec 30, 1993

8/176133

Timothy W. Starzl - Boulder CO
Marguerita Cattell - Loveland CO
Richard T. Mihran - Boulder CO
Loretta M. Zapp - Boulder CO

DDX Incorporated - Boulder CO

A61B 1000

128738

A system is disclosed for making determinations related to the heat cycle in a cow. The system includes an electronic patch attached to the cow. A transmitter module for transmitting heat mount data is contained in a pouch of the electronic patch. A removable and disposable battery is also contained in the pouch for powering the transmitter module. The heat mount data from the transmitter module is sent to a repeater module to maintain the quality of the transmitted heat mount data signal. The heat mount data is re-transmitted by the repeater module to a central receiver module which includes a memory for storing heat mount data. The heat mount data is downloaded to a computer upon request using software that is also used to analyze the heat mount data. Analysis of the heat mount data results in determining a value that is useful in deciding on the optimal time to breed the cow.

59587040, Sep 28, 1999

Mar 12, 1997

8/820365

Timothy W. Starzl - Boulder CO
David W. Nunnery - Westminster CO
MaryBeth Robinson - Boulder CO
H. John Hanlin - Louisville CO

DDx, Inc. - Denver CO

G01N 3353
G01N 33543

435 71

A system for detecting a specific substance or analyte of interest is provided that includes one or more sensing units and an instrument for analyzing the sensing units. Each sensing unit preferably includes a substrate, an attachment layer and at least one capture layer that includes a ligand layer. In one embodiment, the attachment layer is tripartite and includes a lower binding surface held to the substrate and an upper binding surface that holds the ligand layer, together with an insulating layer disposed between these two surfaces. The lower binding surface provides a durable and stable attachment to the substrate. The upper binding surface holds the ligand layer and does not jeopardize the integrity or viability thereof. The insulating layer prevents any unwanted interaction between the lower and upper binding surfaces. Each sensing unit is supported on a test piece received by the instrument.