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Timothy A Mietzner

from Pittsburgh, PA
Age ~65
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Also known as:
Tim A Mietzner
Phone and address:
1341 Cordova Rd, Pittsburgh, PA 15206
(412) 363-6409
Related to:
Charles MietznerSue M Mietzner, 72Daniel A Mietzner, 31
Connected to:
Kyle D Mietzner, 41Steven E Mieure, 75Jeanette A Mieyal, 76Sandra M Miezwa, 77Jennifer M Miff, 51Ashley L Miffitt, 41Jack Mifflin, 85Megan J Mifflin, 38Raymond E Mifflin, 78Rose M Mifflin, 60

Timothy Mietzner Phones & Addresses

  • 1341 Cordova Rd, Pittsburgh, PA 15206 (412) 363-6409
  • Menlo Park, CA
  • Palo Alto, CA

Resumes

Resumes

Timothy Mietzner Photo 1

Associate Professor With Tenure

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Location:
1341 Cordova Rd, Pittsburgh, PA 15206
Industry:
Higher Education
Work:
University of Pittsburgh since Aug 1996
Associate Professor with Tenure
Arizona School of Dentistry and Oral Health Sep 2002 - Nov 2008
Associate Profosser
University of Pittsburgh School of Medicine Oct 1990 - Jul 1996
Assistant professor
Education:
Centers for Disease Control and Prevention 1994 - 1996
Post Doctoral, Microbial Physiology Stanford University School of Medicine 1986 - 1990
Research Associate, Microbiology and Biochemistry Oregon Health and Science University School of Medicine 1981 - 1985
PhD, Microbial Physiology Portland State University 1979 - 1981
Bachelor of Science, Biology Concordia University-Portland 1977 - 1979
In attendance, Biology
Interests:
Website Currently Being Updated
Languages:
English
Timothy Mietzner Photo 2

Professor

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Location:
Pittsburgh, PA
Industry:
Higher Education
Work:
Lake Erie College of Osteopathic Medicine
Professor
Skills:
Molecular Biology
Teaching
Lifesciences
Clinical Research
Research
Pcr
Science
Biochemistry
Life Sciences
Higher Education
Cell Biology
Cell Culture
Grant Writing

Publications

Us Patents

Virus Derived Antimicrobial Peptides

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US Patent:
6835713, Dec 28, 2004
Filed:
Feb 16, 2001
Appl. No.:
09/785059
Inventors:
Ronald C. Montelaro - Wexford PA
Timothy A. Mietzner - Pittsburgh PA
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
A61K 3816
US Classification:
514 12, 514 2, 530300, 530333, 530402, 435 32, 424 91, 424439, 604 19
Abstract:
The invention is directed to peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides of the present invention are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The invention is further directed to peptides referred to as the Lytic Base Unit (LBU) peptides derived from the LLP1 analogs, also having antimicrobial activity. In addition, the present invention is also directed to methods of using the peptides in a variety of contexts, including the treatment or prevention of infectious diseases. The antimicrobial LLP1 analog peptides and the LBU peptides (collectively eLLPs) may be highly active under high salt conditions and in biologic fluids. In addition, the eLLPs are effective when presented either in soluble form, or when attached to a solid surface. Furthermore, the peptides of the present invention are selectively active against a wide variety of bacterial pathogens and exhibit minimal toxicity to eukaryotic cells in vitro and in vivo.

Virus Derived Antimicrobial Peptides

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US Patent:
6887847, May 3, 2005
Filed:
Feb 19, 2002
Appl. No.:
10/079075
Inventors:
Ronald C. Montelaro - Wexford PA, US
Timothy A. Mietzner - Pittsburgh PA, US
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
A61K038/00
A01N025/08
US Classification:
514 2, 514 13, 514 14, 530300, 435174, 424409, 623 11
Abstract:
The invention is directed to peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides of the present invention are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The invention is further directed to peptides referred to as the Lytic Base Unit (LBU) peptides derived from the LLP1 analogs, also having antimicrobial activity. In addition, the present invention is also directed to methods of using the peptides in a variety of contexts, including the treatment or prevention of infectious diseases. The antimicrobial LLP1 analog peptides and the LBU peptides (collectively eLLPs) may be highly active under high salt conditions and in biologic fluids. In addition, the eLLPs are effective when presented either in soluble form, or when attached to a solid surface. Furthermore, the peptides of the present invention are selectively active against a wide variety of bacterial pathogens and exhibit minimal toxicity to eukaryotic cells in vitro and in vivo.

Virus Derived Antimicrobial Peptides

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US Patent:
8071540, Dec 6, 2011
Filed:
Jul 11, 2008
Appl. No.:
12/171806
Inventors:
Ronald C. Montelaro - Wexford PA, US
Timothy A. Mietzner - Pittsburgh PA, US
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
A61K 38/10
A61K 38/16
C07K 7/08
C07K 14/00
US Classification:
514 24, 514 33, 514 34, 514 37, 514 38, 514 214, 514 215, 530325, 530326, 530327
Abstract:
Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The antimicrobial peptides are monomers or multimers of peptides referred to as the Lytic Base Unit (LBU) peptides, derived from the LLP1 analogs and also having antimicrobial activity. Also described herein are using the peptides in a variety of contexts, including the treatment or prevention of infectious diseases. Methods of killing fungi, such as and species, and bacteria, such as , are provided herein. Methods of neutralizing enveloped viruses, such as poxvirus, herpesvirus, rhabdovirus, hepadnavirus, baculovirus, orthomyxovirus, paramyxovirus, retrovirus, togavirus, bunyavirus and flavivirus, including influenza virus and HIV-1 also are provided herein. Solid phase substrates and peptide-cargo complexes comprising the peptides also are provided.

Virus Derived Antimicrobial Peptides

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US Patent:
20030036627, Feb 20, 2003
Filed:
Feb 16, 2001
Appl. No.:
09/785058
Inventors:
Ronald Montelaro - Wexford PA, US
Timothy Mietzner - Pittsburgh PA, US
International Classification:
A61K038/16
C07K014/005
US Classification:
530/324000, 530/326000, 514/012000
Abstract:
The invention is directed to peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides of the present invention are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The invention is further directed to peptides referred to as the Lytic Base Unit (LBU) peptides derived from the LLP1 analogs, also having antimicrobial activity. In addition, the present invention is also directed to methods of using the peptides in a variety of contexts, including the treatment or prevention of infectious diseases. The antimicrobial LLP1 analog peptides and the LBU peptides (collectively eLLPs) may be highly active under high salt conditions and in biologic fluids. In addition, the eLLPs are effective when presented either in soluble form, or when attached to a solid surface. Furthermore, the peptides of the present invention are selectively active against a wide variety of bacterial pathogens and exhibit minimal toxicity to eukaryotic cells in vitro and in vivo.

Clostridium Perfingens Type A Enterotoxin Toxoid And Methods Of Preparation And Use As A Vaccine And Therapeutic Agent

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US Patent:
56959567, Dec 9, 1997
Filed:
Mar 15, 1994
Appl. No.:
8/213452
Inventors:
Bruce A. McClane - Pittsburgh PA
Philip C. Hanna - Charlestown MA
Timothy A. Mietzner - Pittsburgh PA
Assignee:
University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
C12P 2102
US Classification:
435 691
Abstract:
Escherichia coli strains that produce recombinant Clostridium perfringens type A enterotoxin toxoids from a Clostridium perfringens type A enterotoxin gene fragment encoding the Clostridium perfringens type A enterotoxin binding domain subcloned into an expression vector for forming plasmids are disclosed. The Clostridium perfringens type A enterotoxin toxoids of this invention recognize, irreversibly bind to and saturate receptor sites on intestinal membranes and, thus effectively compete for these receptor sites with Clostridium perfringens type A enterotoxin. The toxoids of this invention may be used to treat the symptoms of Clostridium perfringens food poisoning in patients. Vaccines are also disclosed that may be used to prevent the symptoms of Clostridium perfringens food poisoning in patients. Processes for preparing the plasmids and toxoids of this invention and for using the toxoids and vaccines of this invention are also provided.

Antimicrobial Peptides

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US Patent:
59455071, Aug 31, 1999
Filed:
Sep 18, 1997
Appl. No.:
8/932682
Inventors:
Ronald C. Montelaro - Pittsburgh PA
Sarah Burroughs Tencza - Pittsburgh PA
Timothy A. Mietzner - Pittsburgh PA
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
C07K 700
US Classification:
530324
Abstract:
The invention is directed to antimicrobial peptides which correspond in sequence to selective amino acid sequences in viral transmembrane proteins. In particular, the proteins are derived from lentiviruses, primarily HIV and SIV. The peptides comprise arginine-rich sequences, which, when modeled for secondary structure, display a high amphipathicity and hydrophobic moment. They are highly inhibitory to microorganisms, while being significantly less active in regard to mammalian cells. As a result, the peptides of the invention may be defined as selective antimicrobial agents. The invention is also directed to antimicrobial peptides which are structural and functional analogs and homologs of the peptides and which exhibit selective inhibitory activity towards microorganisms. The invention is also directed to pharmaceutical compositions comprising the antimicrobial peptides of the invention and to methods for their use in inhibiting microbial growth and treatment of microbial infections.

Antimicrobial Peptides

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US Patent:
57145776, Feb 3, 1998
Filed:
Jan 24, 1997
Appl. No.:
8/786748
Inventors:
Ronald C. Montelaro - Pittsburgh PA
Sarah Burroughs Tencza - Pittsburgh PA
Timothy A. Mietzner - Pittsburgh PA
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
A61K 3816
C07K 1400
US Classification:
530324
Abstract:
The invention is directed to antimicrobial peptides which correspond in sequence to selective amino acid sequences in viral transmembrane proteins. In particular, the proteins are derived from lentiviruses, primarily HIV and SIV. The peptides comprise arginine-rich sequences, which, when modeled for secondary structure, display a high amphipathicity and hydrophobic moment. They are highly inhibitory to microorganisms, while being significantly less active in regard to mammalian cells. As a result, the peptides of the invention may be defined as selective antimicrobial agents. The invention is also directed to antimicrobial peptides which are structural and functional analogs and homologs of the peptides and which exhibit selective inhibitory activity towards microorganisms. The invention is also directed to pharmaceutical compositions comprising the antimicrobial peptides of the invention and to methods for their use in inhibiting microbial growth and treatment of microbial infections.
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Timothy A Mietzner from Pittsburgh, PA, age ~65 Get Report