US Patent:
20110144064, Jun 16, 2011
Inventors:
Robert Schwarcz - Baltimore MD, US
Roberto Pellicciari - Perugia, IT
Timothy Gately - San Francisco CA, US
International Classification:
A61K 31/662
C12N 5/071
A61K 31/197
A61K 31/19
G01N 33/50
C07C 53/08
C07C 55/02
C07C 309/63
C07F 9/38
A61P 25/00
US Classification:
514143, 435325, 514561, 514574, 514557, 436129, 436104, 436111, 436120, 562512, 562590, 562 30, 562 24
Abstract:
Provided herein are methods of decreasing a level of kynurenic acid in a cell and of treating a pathophysiological condition in a subject associated with an increase in kynurenic acid in a subject. In these methods the inhibitory action of dicarboxylic acids or derivatives or analogs thereof are effective to inhibit activity of kynurenine aminotransferase II. Also provided is a method of screening for potential inhibitory compounds for kynurenine aminotransferase II. The dicarboxylic acids or derivatives or analogs thereof may have the structural formula, where Ris H, NHor NHCH, Ris H or CH, n is 0 to 14, and X is —COOH, CHOH, —POH, —SOH, or —SOH; or a pharmacologically acceptable salt.