Inventors:
Thomas Reppen - Madison WI, US
David Lewis - Madison WI, US
Assignee:
Mirus Bio Corporation - Madison WI
International Classification:
A61K 48/00
C07H 21/02
US Classification:
514044000, 435455000, 536023100
Abstract:
Endogenous gene regulation mechanisms together with microRNAs expressed in many organisms can be used to provide regulated or conditional expression of transgenes by placing an appropriate sequence, a microRNA binding site, within the transcribed gene. This microRNA-dependent transcription regulation can be further regulated using microRNA inhibitors.