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Tara L Deans

from Salt Lake City, UT
Age ~51

Tara Deans Phones & Addresses

  • 2935 E Denmark Dr, Salt Lake Cty, UT 84121
  • Salt Lake City, UT
  • Cottonwood Heights, UT
  • Ellicott City, MD
  • 6324 Victorious Song Ln, Clarksville, MD 21029 (410) 531-2168
  • Somerville, MA
  • Cambridge, MA
  • 1532 E Laird Ave, Salt Lake City, UT 84105 (410) 531-2168

Publications

Us Patents

Tunable Genetic Switch For Regulating Gene Expression

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US Patent:
20100175141, Jul 8, 2010
Filed:
Oct 19, 2007
Appl. No.:
12/446300
Inventors:
James J. Collins - Newton MA, US
Tara L. Deans - Somerville MA, US
International Classification:
A01K 67/00
C12N 15/74
C12N 5/071
A61K 45/00
G01N 33/53
A61P 43/00
US Classification:
800 13, 4353201, 435325, 435366, 424 9321, 435 721
Abstract:
The present invention relates generally the field of genetics, in particular methods, compositions and systems for controlling the inducible expression of transgenes, while eliminating background expression of transgene expression. The present invention relates to methods of use of the compositions and systems as disclosed herein for controlling the inducible expression of transgenes while eliminating background expression of transgene expression, such as use in, for example, the in generation of transgenic animals, use in therapeutic application and use in assays. In some embodiments, the present invention relates to a system of controlled expression of RNAi molecules which target binding sites in the untranslated regions of transgene, thereby the expression of the transgene is modulated and leakiness is reduced. The compositions and methods of the present invention can be used to for therapy, prophylaxis, research and diagnostics in diseases and disorders which afflict mammalian species, generation of transgenic animals, in the study of biological processes as well as for enhance performance of agricultural crops.

Methods Of Engineering Platelets For Targeting Circulating Tumor Cells

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US Patent:
20220348938, Nov 3, 2022
Filed:
Sep 30, 2020
Appl. No.:
17/765872
Inventors:
- Salt Lake City UT, US
Tara Deans - Salt Lake City UT, US
International Classification:
C12N 15/63
A61K 35/19
C12N 5/078
C07K 16/30
A61P 35/00
Abstract:
Disclosed herein are nucleic acid constructs that can be used to build genetic circuits for producing antibodies comprising split toxins. Also disclosed herein are methods of producing platelets comprising the antibodies. The platelets produced by the methods disclosed herein can be used to target circulating tumor cells.

Methods Of Making Red Blood Cells And Platelets In Vitro And Uses Thereof

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US Patent:
20220251510, Aug 11, 2022
Filed:
Apr 15, 2022
Appl. No.:
17/721690
Inventors:
- Salt Lake City UT, US
Tara L. Deans - Cottonwood Heights UT, US
International Classification:
C12N 5/078
C12N 5/0789
C12N 15/85
Abstract:
Disclosed herein are methods of producing platelets and red blood cells using synthetic biology and uses thereof. The methods disclosed herein can also be used to produce platelets and red blood cells comprising a therapeutic agent. The cells produced by the methods disclosed herein can be used to treat, manage, prevent and diagnosis various diseases and disorders and be used as a research tool.

Methods Of Making Red Blood Cells And Platelets In Vitro And Uses Thereof

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US Patent:
20190010456, Jan 10, 2019
Filed:
Jul 13, 2016
Appl. No.:
15/745305
Inventors:
- Salt Lake City UT, US
Tara L. DEANS - Cottonwood Heights UT, US
International Classification:
C12N 5/078
C12N 5/0789
C12N 5/074
C12N 15/85
Abstract:
Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats; and, non-immunogenic bioconjugates comprising recombinant polypeptides comprising one or more homologous amino acid repeats and one or more therapeutic agents. Also, disclosed herein are pharmaceutical compositions including the recombinant polypeptides; and methods of administering the recombinant polypeptides to patients for the treatment of cancer or infections.
Tara L Deans from Salt Lake City, UT, age ~51 Get Report