Resumes
Resumes
Tabassum Naqvi Phones & Addresses
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3165 Baylis St, Fremont, CA 94538 (510) 623-9495
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Hayward, CA
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Sunnyvale, CA
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Chicago, IL
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458 5Th St, San Jose, CA 95112
Business Records
Name / Title
Company / Classification
Phones & Addresses
Group Leader Chemistry
DISCOVERX CORPORATION
Commercial Physical Research · Research and Development in the Physical, Engineering, and L
Commercial Physical Research · Research and Development in the Physical, Engineering, and L
42501 Albrae St SUITE 100, Fremont, CA 94538
(510) 979-1415
(510) 979-1415
Publications
Us Patents
Lactamase Amplification Substrate
View pageUS Patent:
7537910, May 26, 2009
Filed:
Jun 8, 2006
Appl. No.:
11/449414
Inventors:
Rajendra Singh - San Jose CA, US
Tabassum Naqvi - Fremont CA, US
Tabassum Naqvi - Fremont CA, US
Assignee:
Discoverx Corp. - Fremont CA
International Classification:
C12Q 1/54
US Classification:
435 14, 435 32
Abstract:
An amplifiable β-lactamase substrate is provided comprising an enzyme donor fragment of β-galactosidase linked to form a ring to a β-lactam ring that is a substrate for lactamase and upon opening of the β-lactam ring the enzyme donor fragment becomes linearized. The cyclic substrate only weakly binds to the enzyme acceptor fragment of β-galactosidase. The substrate finds application for the sensitive detection of β-lactamase for direct detection of the enzyme or when the enzyme is used as a label.
Short Enzyme Donor Fragment
View pageUS Patent:
20030219848, Nov 27, 2003
Filed:
Apr 24, 2003
Appl. No.:
10/422262
Inventors:
Tabassum Naqvi - Fremont CA, US
Rajendra Singh - San Jose CA, US
Riaz Rouhani - Concord CA, US
Rajendra Singh - San Jose CA, US
Riaz Rouhani - Concord CA, US
International Classification:
C12Q001/34
C07H021/04
C12N009/40
C12P021/02
C12N005/06
C07H021/04
C12N009/40
C12P021/02
C12N005/06
US Classification:
435/018000, 435/069100, 435/320100, 435/325000, 435/208000, 536/023200
Abstract:
Short enzyme donor fragments of -galactosidase are provided of not more than 40 amino acids, where the short fragments are used as a label and may be substituted with a wide variety of organic compounds, particularly polypeptides having independent functional activity. The enzyme donor finds use in competitive and non-competitive assays, monitoring intracellular events, or other processes where a sensitive non-interfering label is desired.
Receptor Detection
View pageUS Patent:
20040018562, Jan 29, 2004
Filed:
May 29, 2003
Appl. No.:
10/448609
Inventors:
Riaz Rouhani - Concord CA, US
Tabassum Naqvi - Fremont CA, US
Rajendra Singh - San Jose CA, US
Tabassum Naqvi - Fremont CA, US
Rajendra Singh - San Jose CA, US
International Classification:
G01N033/53
G01N033/567
G01N033/567
US Classification:
435/007100, 435/007200
Abstract:
Improved results are obtained using in an enzyme fragment complementation assay, as an enzyme donor a fragment of -galactosidase of from 36 to 50 amino acids joined to a ligand capable of binding to a receptor other than an immunoglobulin or fragment thereof. Conveniently, for enzyme assays, enzyme binding site inhibitors are conjugated to the enzyme donor, whereby binding of the enzyme to the binding site inhibitor results in a reduction in the turnover rate of -galactosidase in the presence of EA and a substrate capable of producing a detectable signal. Analogously, ligands for membrane receptors may be conjugated to the ED for measurement of membrane receptors.
Ip3 Protein Binding Assay
View pageUS Patent:
20040106158, Jun 3, 2004
Filed:
Oct 20, 2003
Appl. No.:
10/689122
Inventors:
Tabassum Naqvi - Fremont CA, US
Riaz Rouhani - Concord CA, US
Peter Fung - Sunnyvale CA, US
Richard Eglen - Los Altos CA, US
Rajendra Singh - San Jose CA, US
Riaz Rouhani - Concord CA, US
Peter Fung - Sunnyvale CA, US
Richard Eglen - Los Altos CA, US
Rajendra Singh - San Jose CA, US
International Classification:
G01N033/53
US Classification:
435/007900
Abstract:
Protein binding assays are provided for determining IPin a sample employing as reagents a conjugate of IPjoined at the 2-oxy through a bond or linking group to a detectable label and a truncated portion of the extracellular fragment of an IPR. The reagents are combined with the sample and the amount of IPdetermined by means of the detectable label. The conjugate with the enzyme donor fragment of -galactosidase or a fluorescer is specifically described.