US Patent:
20040116673, Jun 17, 2004
Inventors:
Jean-Luc Montchamp - Fort Worth TX, US
Sylvine Deprele - Fort Worth TX, US
Assignee:
Texas Christian University
International Classification:
C07F009/22
C07J001/00
US Classification:
530/362000, 546/021000, 552/506000, 558/115000, 558/156000
Abstract:
A novel class of compounds, i.e., 1,1-bis-H-phosphinates (or 1,1-bis-H-phosphinic acid derivatives) are provided. Also provided are novel methods for producing 1,1-bis-H-phosphinates and 1,1-bis-H-phosphinate conjugates. These compounds and conjugates are used as precursors of bisphosphonates and bisphosphonate conjugates, respectively, or as prodrugs directly for treating bone-related and various other diseases.