Inventors:
Rodney Kellems - Houston TX, US
Surjit Datta - Houston TX, US
Michael Blackburn - Pearland TX, US
Assignee:
Board of Regents, The University of Texas System
International Classification:
A01K067/027
C12N005/06
US Classification:
800/018000, 435/354000, 435/320100
Abstract:
The present invention relates to the production of adenosine deaminase (ADA) deficient mice and the use of such mice as an animal model for dysfunctions associated with elevated adenosine levels. Also, provided by the present invention are methods of treating dysfunctions associated with elevated adenosine levels and methods of screening compounds for pharmaceutical activity in the treatment of dysfunctions associated with elevated adenosine levels.