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Sunil K Kc

from San Diego, CA
Age ~54
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Also known as:
Sunil Kumar Kc, Kc K Sunil
Phone and address:
10504 Clasico Ct, San Diego, CA 92127
(858) 618-5543
Related to:
Stephanie H Hagen, 65William J Blalack, 96Srijana Kc, 53Sadiksha Kc, 32Sadiksha Kc, 28Subheksha Kc, 30
Connected to:
Aparna Kc, 45Bal B Kc, 42Bhakta B Kc, 54Bimal Kc, 38David H Kc, 34Manju Kc, 39Nagendra Kc, 65Pragati Kc, 37Prajani Kc, 42Rajiv Kc, 39

Sunil Kc Phones & Addresses

  • 10504 Clasico Ct, San Diego, CA 92127 (858) 618-5543
  • 8155 Cargill Ave, San Diego, CA 92122 (858) 450-0976
  • Lake Elsinore, CA
  • Omaha, NE

Resumes

Resumes

Sunil Kc Photo 1

Vice President, Chemistry

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Location:
10504 Clasico Ct, San Diego, CA 92127
Industry:
Research
Work:
Samumed, Llc Jan 2015 - Mar 2017
Senior Director, Chemistry
Samumed, Llc Jan 2015 - Mar 2017
Vice President, Chemistry
Samumed, Llc Feb 2009 - Jan 2015
Director, Chemistry
Yagadol Apr 2007 - Dec 2008
Associate Director
Avanir Pharmaceuticals Oct 2001 - Apr 2007
Associate Director of Chemistry
Education:
Uc San Diego 2012 - 2012
University of Regensburg 1996 - 1999
University of California
Skills:
Medicinal Chemistry
Drug Discovery
Drug Design
Drug Development
Pharmaceutical Industry
Chemistry
Organic Synthesis
Nmr
Organic Chemistry
Biotechnology
Lc Ms
Lead Change
Oncology
Parallel Synthesis
Peptides
Synthetic Organic Chemistry
Asymmetric Synthesis
Heterocyclic Chemistry
Combinatorial Chemistry
Peptide Synthesis
Languages:
English
Sunil Kc Photo 2

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Publications

Us Patents

Indazole Inhibitors Of The Wnt Signal Pathway And Therapeutic Uses Thereof

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US Patent:
8604052, Dec 10, 2013
Filed:
Jul 10, 2013
Appl. No.:
13/938691
Inventors:
David Mark Wallace - San Diego CA, US
Sunil Kumar KC - San Diego CA, US
Assignee:
Samumed, LLC - San Diego CA
International Classification:
A01N 43/42
A61K 31/44
C07D 513/02
C07D 515/02
US Classification:
514303, 546118
Abstract:
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e. g. , cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Β- And Γ-Diketones And Γ-Hydroxyketones As /Β-Catenin Signaling Pathway Activators

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US Patent:
8609717, Dec 17, 2013
Filed:
Aug 17, 2011
Appl. No.:
13/211665
Inventors:
Sunil Kumar KC - San Diego CA, US
David Mark Wallace - San Diego CA, US
John Hood - San Diego CA, US
Charlene F. Barroga - San Diego CA, US
Assignee:
Samumed, LLC - San Diego CA
International Classification:
C07D 319/18
A61K 31/357
US Classification:
514452, 514456, 514465, 549362, 549405, 549436
Abstract:
The present invention discloses β-diketones, γ-diketones or γ-hydroxyketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

1H-Pyrazolo[3,4-]Pyridines And Therapeutic Uses Thereof

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US Patent:
8618128, Dec 31, 2013
Filed:
Sep 5, 2013
Appl. No.:
14/019147
Inventors:
Sunil Kumar KC - San Diego CA, US
David Mark Wallace - San Diego CA, US
Assignee:
Samumed, LLC - San Diego CA
International Classification:
A01N 43/42
C07D 471/02
C07D 491/02
C07D 498/02
US Classification:
514300, 546119
Abstract:
Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases.

Inhibitors Of Protein Kinase For The Treatment Of Disease

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US Patent:
20030187007, Oct 2, 2003
Filed:
May 28, 2002
Appl. No.:
10/158030
Inventors:
Sheldon Cao - Carlsbad CA, US
Pierre-Yves Bounaud - San Diego CA, US
Xiaohua Chen - San Diego CA, US
Hyun-Ho Chung - San Diego CA, US
Sunil KC - San Diego CA, US
Changhee Min - San Diego CA, US
Jae Yang - Carlsbad CA, US
Melissa Long - San Diego CA, US
International Classification:
A61K031/44
A61K031/40
A61K031/165
A61K031/21
A01N031/08
A61K031/05
A61K031/12
US Classification:
514/277000, 514/408000, 514/678000, 514/622000, 514/736000, 546/339000, 548/557000, 560/138000, 560/130000, 564/158000, 568/333000, 568/744000
Abstract:
The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to phenol- and hydroxynaphthalene-based compounds and pharmaceutical compositions comprising these compounds.

Inhibitors Of Macrophage Migration Inhibitory Factor And Methods For Identifying The Same

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US Patent:
20070179132, Aug 2, 2007
Filed:
Mar 16, 2007
Appl. No.:
11/687541
Inventors:
Jagadish Sircar - San Diego CA, US
Sunil KC - San Diego CA, US
Wenbin Ying - San Diego CA, US
Assignee:
Avanir Pharmaceuticals - San Diego CA
International Classification:
A61K 31/551
A61K 31/496
C07D 403/04
US Classification:
514218000, 514253070, 540575000, 544363000
Abstract:
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R, R, R, R, X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

Indazoles As Wnt/B-Catenin Signaling Pathway Inhibitors And Therapeutic Uses Thereof

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US Patent:
20110034441, Feb 10, 2011
Filed:
Aug 9, 2010
Appl. No.:
12/852681
Inventors:
John Hood - San Diego CA, US
Sunil Kumar KC - San Diego CA, US
Assignee:
EPITHERIX, LLC - San Diego CA
International Classification:
A61K 31/551
A61K 31/4184
A61K 31/454
A61K 31/496
A61K 31/5377
A61K 31/541
A61K 31/437
A61K 31/416
A61K 31/4178
A61K 31/4439
A61P 35/00
A61P 31/10
A61P 31/12
A61P 19/02
A61P 17/06
A61P 27/06
A61P 25/28
A61P 3/10
A61P 3/04
A61P 19/10
A61P 43/00
US Classification:
514218, 514394, 514322, 51425406, 5142345, 5142282, 514303, 514403, 514392, 514338
Abstract:
Described herein are methods of treating a disorder or disease in which aberrant Wnt signaling is implicated, with a variety of compounds, including Wnt inhibitor compounds. More particularly, it concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components.

Indazole Inhibitors Of The Wnt Signal Pathway And Therapeutic Uses Thereof

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US Patent:
20110034497, Feb 10, 2011
Filed:
Aug 9, 2010
Appl. No.:
12/852706
Inventors:
John Hood - San Diego CA, US
David Mark Wallace - San Diego CA, US
Sunil Kumar KC - San Diego CA, US
Assignee:
EPITHERIX, LLC - San Diego CA
International Classification:
A61K 31/505
C07D 471/04
A61K 31/437
A61K 31/506
A61P 35/00
A61P 3/10
A61P 19/02
A61P 27/06
A61P 31/12
A61P 25/28
A61P 17/06
US Classification:
514275, 546118, 514303, 544333, 514256, 544331
Abstract:
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

1H-Pyrazolo[3,4-B]Pyridines And Therapeutic Uses Thereof

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US Patent:
20110190290, Aug 4, 2011
Filed:
Dec 15, 2010
Appl. No.:
12/968505
Inventors:
John Hood - San Diego CA, US
Sunil Kumar KC - San Diego CA, US
David Mark Wallace - San Diego CA, US
Assignee:
EPITHERIX, LLC - San Diego CA
International Classification:
A61K 31/5377
C07D 471/04
A61K 31/437
A61K 31/496
C07D 413/14
A61P 35/00
A61P 3/10
A61P 19/02
A61P 17/06
A61P 31/12
A61P 25/28
US Classification:
5142342, 546119, 514303, 544362, 51425304, 544127
Abstract:
Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:
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Sunil K Kc from San Diego, CA, age ~54 Get Report