Stavros G Demos

6665556, Dec 16, 2003

Jan 28, 2000

09/493939

Robert R. Alfano - Bronx NY, 10463
Stavros G. Demos - Livermore CA, 94550
Gang Zhang - Edison NJ, 08817

A61B 600

600473, 600476, 600474, 600477

Method and an apparatus for examining a tissue using the spectral wing emission therefrom induced by visible to infrared photoexcitation. In one aspect, the method is used to characterize the condition of a tissue sample and comprises the steps of (a) photoexciting the tissue sample with substantially monochromatic light having a wavelength of at least 600 nm; and (b) using the resultant far red and near infrared spectral wing emission (SW) emitted from the tissue sample to characterize the condition of the tissue sample. In one embodiment, the substantially monochromatic photoexciting light is a continuous beam of light, and the resultant steady-state far red and near infrared SW emission from the tissue sample is used to characterize the condition of the tissue sample. In another embodiment, the substantially monochromatic photoexciting light is a light pulse, and the resultant time-resolved far red and near infrared SW emission emitted from the tissue sample is used to characterize the condition of the tissue sample. In still another embodiment, the substantially monochromatic photoexciting light is a polarized light pulse, and the parallel and perpendicular components of the resultant polarized time-resolved SW emission emitted from the tissue sample are used to characterize the condition of the tissue sample.

7016717, Mar 21, 2006

Jul 5, 2002

10/190231

Stavros Demos - Livermore CA, US
Michael C. Staggs - Tracy CA, US

The Regents of the University of California - Oakland CA

A61B 6/00

600473

Near infrared imaging using elastic light scattering and tissue autofluorescence are explored for medical applications. The approach involves imaging using cross-polarized elastic light scattering and tissue autofluorescence in the Near Infra-Red (NIR) coupled with image processing and inter-image operations to differentiate human tissue components.

7149567, Dec 12, 2006

Dec 2, 2005

11/293590

Stavros Demos - Livermore CA, US
Michael C. Staggs - Tracy CA, US

The Regents of the University of California - Oakland CA

A61B 6/00

600473

Near infrared imaging using elastic light scattering and tissue autofluorescence are explored for medical applications. The approach involves imaging using cross-polarized elastic light scattering and tissue autofluorescence in the Near Infra-Red (NIR) coupled with image processing and inter-image operations to differentiate human tissue components.

7257437, Aug 14, 2007

Mar 25, 2003

10/400024

Stavros G. Demos - Livermore CA, US
Ralph W. deVere White - Sacramento CA, US

The Regents of the University of California - Oakland CA

A61B 6/00
G02F 1/01

600473, 250330

Near infrared imaging using elastic light scattering and tissue autofluorescence and utilizing interior examination techniques and equipment are explored for medical applications. The approach involves imaging using cross-polarized elastic light scattering and/or tissue autofluorescence in the Near Infra-Red (NIR) coupled with image processing and inter-image operations to differentiate human tissue components.

7426028, Sep 16, 2008

Mar 14, 2006

11/375882

Christopher W. Carr - Livermore CA, US
Stavros Demos - Livermore CA, US
Michael D. Feit - Livermore CA, US
Alexander M. Rubenchik - Livermore CA, US

Lawrence Livermore National Security, LLC - Livermore CA

G01J 3/28

356326, 356330, 365120, 365106

Optical breakdown by predetermined laser pulses in transparent dielectrics produces an ionized region of dense plasma confined within the bulk of the material. Such an ionized region is responsible for broadband radiation that accompanies a desired breakdown process. Spectroscopic monitoring of the accompanying light in real-time is utilized to ascertain the morphology of the radiated interaction volume. Such a method and apparatus as presented herein, provides commercial realization of rapid prototyping of optoelectronic devices, optical three-dimensional data storage devices, and waveguide writing.

7587236, Sep 8, 2009

Jan 8, 2005

11/031936

Stavros Demos - Livermore CA, US
Jason Fitzgerald - Sacramento CA, US
Christoph Troppmann - Sacramento CA, US
Andromachi Michalopoulou - Athens, GR

Lawrence Livermore National Security, LLC - Livermore CA

A61B 6/00

600477, 600473, 600476

An optical method and apparatus is utilized to quantify ischemic tissue and/or organ injury. Such a method and apparatus is non-invasive, non-traumatic, portable, and can make measurements in a matter of seconds. Moreover, such a method and apparatus can be realized through optical fiber probes, making it possible to take measurements of target organs deep within a patient's body. Such a technology provides a means of detecting and quantifying tissue injury in its early stages, before it is clinically apparent and before irreversible damage has occurred.

7945077, May 17, 2011

Nov 30, 2005

11/292406

Stavros G. Demos - Livermore CA, US

Lawrence Livermore National Security, LLC - Livermore CA

G06K 9/00

382128, 600473

An optical hyperspectral/multimodal imaging method and apparatus is utilized to provide high signal sensitivity for implementation of various optical imaging approaches. Such a system utilizes long working distance microscope objectives so as to enable off-axis illumination of predetermined tissue thereby allowing for excitation at any optical wavelength, simplifies design, reduces required optical elements, significantly reduces spectral noise from the optical elements and allows for fast image acquisition enabling high quality imaging in-vivo. Such a technology provides a means of detecting disease at the single cell level such as cancer, precancer, ischemic, traumatic or other type of injury, infection, or other diseases or conditions causing alterations in cells and tissue micro structures.

8190242, May 29, 2012

Jul 22, 2009

12/507585

Stavros G. Demos - Livermore CA, US
Miroslav Y. Shverdin - Sunnyvale CA, US
Michael D. Shirk - Brentwood CA, US

Lawrence Livermore National Security, LLC - Livermore CA

A61B 6/00
G02F 1/35

600473, 600476, 359327

Portable, field-deployable laser synthesizer devices designed for multi-dimensional spectrometry and time-resolved and/or hyperspectral imaging include a coherent light source which simultaneously produces a very broad, energetic, discrete spectrum spanning through or within the ultraviolet, visible, and near infrared wavelengths. The light output is spectrally resolved and each wavelength is delayed with respect to each other. A probe enables light delivery to a target. For multidimensional spectroscopy applications, the probe can collect the resulting emission and deliver this radiation to a time gated spectrometer for temporal and spectral analysis.