Sonia E Letant

7042570, May 9, 2006

Jan 9, 2003

10/339163

Michael J. Sailor - La Jolla CA, US
Sonia Letant - Livermore CA, US

The Regents of the University of California - Oakland CA

G01N 21/55
C12M 1/34

356445, 4352871

A method for analyzing gaseous or liquid samples is provided. Samples are interacted with pores of a porous thin film. A time-varying response of reflectivity is obtained from the surface of the porous thin film during the interaction. One or more analytes forming the sample or a part of the sample are identified based upon the time-varying response.

7155076, Dec 26, 2006

Apr 27, 2004

10/833573

Sonia E. Letant - Livermore CA, US
Anthony Van Buuren - Livermore CA, US
Louis Terminello - Danville CA, US
Bradley R. Hart - Brentwood CA, US

The Regents of the University of California - Oakland CA

G02B 6/00
G02B 6/10

385 12, 385 14, 385129, 385130

Disclosed herein is a porous silicon filter capable of binding and detecting biological and chemical target molecules in liquid or gas samples. A photonic waveguiding silicon filter with chemical and/or biological anchors covalently attached to the pore walls bind target molecules. The system uses transmission curve engineering principles to allow measurements to be made in situ and in real time to detect the presence of various target molecules and calculate the concentration of bound target.

8059924, Nov 15, 2011

Sep 8, 2008

12/206337

Sonia E. Letant - Livermore CA, US
Tiziana C. Bond - Livermore CA, US

Lawrence Livermore National Security, LLC - Livermore CA

G02B 6/00
G01N 21/01
H04J 14/02
A61B 5/00

385 12, 385 14, 385122, 385130, 385131, 356244, 398 79, 600310, 600364, 600407

Photonic detection systems and methods are shown. A flow through photonic membrane is provided with pores which are distributed along multiple regions. The pores of one region have walls to which a first type of target specific anchor can be attached, while pores of another region have walls to which a second type of target specific anchor can be attached. An additional region of pores without anchors can be provided, so that optical detection occurs differentially. A stack of photonic membranes is also provided. The diameter of the pores of one photonic membrane is larger than the diameter of the pores of another photonic membrane, thus allowing also determination of the size of a target organism flown through the stack of membranes.

20020191884, Dec 19, 2002

May 31, 2002

10/159175

Sonia Letant - Livermore CA, US
Anthony Buuren - Livermore CA, US
Louis Terminello - Danville CA, US

The Regents of the University of California

G02B006/26
G02B006/10
G01N033/48

385/012000, 702/019000, 385/129000

Disclosed herein is a photonic silicon filter capable of binding and detecting biological and chemical target molecules in liquid or gas samples. A photonic waveguiding silicon filter with chemical and/or biological anchors covalently attached to the pore walls selectively bind target molecules. The system uses transmission curve engineering principles to allow measurements to be made in situ and in real time to detect the presence of various target molecules and determine the concentration of bound target.

20050074778, Apr 7, 2005

Oct 1, 2003

10/677395

Sonia Letant - Livermore CA, US
Anthony Buuren - Livermore CA, US
Louis Terminello - Danville CA, US
Michael Thelen - Danville CA, US
Louisa Hope-Weeks - Brentwood CA, US
Bradley Hart - Brentwood CA, US

C12Q001/68
C12M001/34

435006000, 435287200

Disclosed are nanometer to micron scale functionalized apertures constructed on a substrate made of glass, carbon, semiconductors or polymeric materials that allow for the real time detection of biological materials or chemical moieties. Many apertures can exist on one substrate allowing for the simultaneous detection of numerous chemical and biological molecules. One embodiment features a macrocyclic ring attached to cross-linkers, wherein the macrocyclic ring has a biological or chemical probe extending through the aperture. Another embodiment achieves functionalization by attaching chemical or biological anchors directly to the walls of the apertures via cross-linkers.

20050287523, Dec 29, 2005

May 26, 2005

11/140391

Sonia Letant - Livermore CA, US
Anthony van Buuren - Livermore CA, US
Louisa Hope-Weeks - Lubbock TX, US
Louis Terminello - Danville CA, US

C12Q001/70
C12M001/34

435005000, 435287100

A system for characterization of a single molecule or cell sample by directing a beam onto the sample to produce energy emanating from the sample. A periodic sample holder with through-pores containing the sample is positioned to receive the beam. At least one pore is provided in the sample holder for holding the sample. The energy emanating from the sample is detected by a detector. The sample holder can be used to study individual molecules, viruses, or cells by various techniques including x-ray diffraction, chemical analysis, optical or electron microscopy, or electrochemistry.

20060204428, Sep 14, 2006

Jan 23, 2006

11/338512

Aleksandr Noy - Belmont CA, US
Olgica Bakajin - San Leandro CA, US
Sonia Letant - Livermore CA, US
Michael Stadermann - Dublin CA, US
Alexander Artyukhin - Menlo Park CA, US

C01B 31/02
C01B 31/00

42344500R

A sensor apparatus comprising a nanotube or nanowire, a lipid bilayer around the nanotube or nanowire, and a sensing element connected to the lipid bilayer. Also a biosensor apparatus comprising a gate electrode; a source electrode; a drain electrode; a nanotube or nanowire operatively connected to the gate electrode, the source electrode, and the drain electrode; a lipid bilayer around the nanotube or nanowire, and a sensing element connected to the lipid bilayer.

20070085010, Apr 19, 2007

Jun 8, 2006

11/450089

Sonia Letant - Livermore CA, US
Chin Cheung - Lincoln NE, US

G01T 1/20

25036100R

A scintillator comprising a matrix material body and nano-material scintillator media carried by the matrix body. One embodiment provides a scintillator apparatus comprising a matrix material body with nano-material scintillator media carried by the matrix body. In one embodiment the nano-material scintillator media is quantum dots. In another embodiment the nano-material scintillator media is nanowires.