Shulamit Levenberg

20050031598, Feb 10, 2005

Dec 9, 2003

10/731672

Shulamit Levenberg - Brighton MA, US
Ngan Huang - Berkeley CA, US
Erin Lavik - New Haven CT, US
Joseph Itskovitz-Eldor - Haifa, IL
Robert Langer - Newton MA, US

C12N005/08

424093700, 435366000

A method of producing a tissue engineering construct. The method includes providing a population of embryonic stem cells, seeding the embryonic stem cells on a cell support matrix, and exposing the embryonic stem cells to at least one agent selected to promote differentiation of the stem cells along a predetermined cell lineage or into a specific cell type. The step of exposing may be performed before or after the step of seeding.

20040009589, Jan 15, 2004

Mar 25, 2003

10/396082

Shulamit Levenberg - Brighton MA, US
Michal Amit - Misgav, IL
Joseph Itskovitz-Eldor - Haifa, IL
Robert Langer - Newton MA, US

C12N005/08

435/366000

The invention is a population of embryonic endothelial cells produced in vitro from human embryonic stem cells. The cells produce platelet endothelial cell adhesion molecule-1 and are vasculogenic. The cells may be combined with a cell support substrate, seeded on a polymer matrix, or combined with a cell-support substrate that is infused into a polymer matrix. The cells may also be injected directly into a tissue site.