Shmuel S Sternberg

6491819, Dec 10, 2002

Sep 18, 2001

09/954734

Paul R. Prince - San Juan Capistrano CA
Michael O. Pekkarinen - Lincolnshire IL
David Bellamy, Jr. - Kenilworth IL
Shmuel Sternberg - Northbrook IL

Baxter International Inc. - Deerfield IL

B01D 6114

21032167, 21032168, 21032187, 21049701

An apparatus is disclosed for separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force or faster rate than the second type of particle. A housing is provided having a generally cylindrical inner surface in which is mounted a rotor having a generally cylindrical outer surface. The outer surface of the rotor is spaced from the inner surface of the housing to define a suspension processing gap. A filter membrane is provided on the surface of the rotor or the housing that has pores with substantially precisely dimensioned shapes and sizes to correspond substantially to the shape of the first type of particle, thus allowing passage of the first type of particle and blocking passage of the second type of particle. A suspension is directed into the processing gap for either a selected residence time in contact with the filter membrane and/or at a selected force.

6497821, Dec 24, 2002

May 17, 1999

09/312883

David Bellamy, Jr. - Kenilworth IL
Paul R. Prince - San Juan Capistrano CA
Michael O. Pekkarinen - Lincolnshire IL
Shmuel Sternberg - Northbrook IL

Baxter International Inc. - Deerfield IL

B01D 6100

210651, 210137, 210138, 21050022, 210636, 210637, 210650

A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force and/or faster rate than the second type of particle. A filter member is provided having substantially precisely dimensioned pore sizes, with the pores being dimensioned to allow passage of the first type of suspended particle without distortion or only minimal distortion and passage of the second type of particle only with substantial distortion. Because the filter membrane has precisely dimensioned pores, with spacing between the pores being maintained despite the smaller interval between the pores, the porosity of the membrane may be much greater than nominal pore size membranes, allowing faster filtration rates and/or smaller membranes for a given filtration rate, while reducing the exposure time of the cells within the shear environment, and consequently reducing particle damage. Various methods for preventing clogging of the membrane are also disclosed.

6576201, Jun 10, 2003

Jan 28, 2000

09/493848

Lecon Woo - Libertyville IL
Daniel R. Boggs - Lake Bluff IL
Shmuel Sternberg - Palatine IL
Craig Sandford - Wheeling IL
Atul Khare - Crystal Lake IL
Julian Breillatt - Mundelein IL

Baxter International Inc. - Deerfield IL

B01J 1908

422186, 4221863, 422210, 422748

A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device ( ) comprises a radiation permeable cylindrical tube ( ) having a concentric cylindrical rotor ( ) disposed therein, thereby providing a thin gap ( ) therebetween. A top plate ( ) having a fluid outlet ( ) and a bottom plate ( ) having a fluid inlet ( ) seal the cylindrical tube ( ). The inlet ( ) and outlet ( ) are both in fluid communication with the thin gap ( ). A rotor shaft ( ) is disposed axially through the cylindrical rotor ( ) and is connected to a motor ( ). A pump provides fluid flow through the device ( ). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube ( ).

6596230, Jul 22, 2003

Jan 28, 2000

09/494338

Lecon Woo - Libertyville IL
Daniel R. Boggs - Lake Bluff IL
Shmuel Sternberg - Palatine IL
Craig Sandford - Wheeling IL
Atul Khare - Crystal Lake IL
Julian Breillatt - Mundelein IL

Baxter International Inc. - Deerfield IL

A61L 208

422 22, 422 44, 422 24, 250433

A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a âcarryingâ mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber ( ) connected to a fluid flow through an inlet ( ) and an outlet ( ) on the belt chamber ( ). The belt chamber ( ) has a top surface ( ) and a bottom surface ( ). A radiation permeable plate ( ) is disposed adjacent the top surface ( ) of the belt chamber ( ) and is in contact with the belt chamber ( ). A radiation source ( ) is provided adjacent to the plate ( ) adjacent to a side opposite the belt chamber ( ).

6612447, Sep 2, 2003

Jul 24, 2000

09/624308

Shmuel Sternberg - Palatine IL

Baxter International Inc. - Deerfield IL

B01D 2956

210489, 210252, 2102571, 210435, 210483, 210488, 21050041, 210503, 210505

A filter for removing leukocytes from blood comprises a filter media enclosed in a housing. The filter media includes a main filter region comprising a porous membrane structure extending between first and second skin surfaces. The porous membrane structure is formed by intersecting cells having a range of diameters. The cells adjacent to the first skin surface have diameters generally smaller than the diameters of the cells adjacent to the second skin surface. The first skin surface includes an open area defined by pores, which are formed by the intersection of cells with the first skin surface. The majority of the open area is defined by pores having a diameter of between about 12 m and 28 m.

6824688, Nov 30, 2004

Jun 26, 2003

10/606589

Shmuel Sternberg - Palatine IL

Baxter International Inc. - Deerfield IL

B01D 3700

210649, 210650

A filter for removing leukocytes from blood comprises a filter media enclosed in a housing. The filter media includes a main filter region comprising a porous membrane structure extending between first and second skin surfaces. The porous membrane structure is formed by intersecting cells having a range of diameters. The cells adjacent to the first skin surface have diameters generally smaller than the diameters of the cells adjacent to the second skin surface. The first skin surface includes an open area defined by pores, which are formed by the intersection of cells with the first skin surface. The majority of the open area is defined by pores having a diameter of between about 12 m and 28 m.

6899834, May 31, 2005

Nov 30, 2001

09/997822

Daniel R. Boggs - Libertyville IL, US
Shmuel Sternberg - Palatine IL, US
Robin G. Pauley - Lake Villa IL, US
Donna L. McLarty - Hoffman Estates IL, US

Baxter International Inc. - Deerfield IL

B29D033/48

264 451, 264 41, 427245, 2105021, 210490, 21050036, 21050042, 2105003, 21050034, 21050029

Membranes and methods for making membranes are disclosed. The membranes include a polymeric matrix and a particulate material immobilized within the matrix. The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.

6908553, Jun 21, 2005

Jul 8, 1998

09/111915

Daniel R. Boggs - Libertyville IL, US
Shmuel Sternberg - Palatine IL, US
Robin G. Pauley - Lake Villa IL, US
Donna L. McLarty - Hoffman Estates IL, US

Baxter International Inc. - Deerfield IL

B01D039/00

2105012, 21050027, 210 5029, 21050036, 21050042, 210490

Membranes and methods for making membranes are disclosed. The membranes include a polymeric matrix and a particulate material immobilized within the matrix. The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.