US Patent:
20110313229, Dec 22, 2011
Inventors:
Kiminobu Sugaya - Winter Park FL, US
Angel Alvarez - Chicago IL, US
Sergey Bushnev - Altamonte Springs FL, US
Nicholas G. Avgeropoulos - Orlando FL, US
International Classification:
A61N 5/00
C12N 5/095
A61P 37/04
A61K 31/713
A61P 35/00
A61K 39/00
C12N 5/0784
US Classification:
600 1, 4242771, 435374, 435375, 514 44 A
Abstract:
Disclosed herein are new immunotherapy methods that involve the isolation of cancer stem cells from tumor tissue and use of the cells either directly or indirectly through proteins or other factors associated with the cells to activate antigen presenting cells. The activated antigen presenting cells are useful as a therapy against the tumor. Also disclosed herein are novel methods of isolating and characterizing cancer stem cells and producing individual cancer stem cell lines. Dendritic cell lines are also disclosed herein.