Inventors:
Michael Bolger - Los Alamitos CA
Kelvin W. Gee - Hacienda Heights CA
Nancy C. Lan - S. Pasadena CA
Delia Belelli - Rowland Heights CA
Seid Mirsadeghi - Sherman Oaks CA
Robert Purdy - San Antonio TX
Assignee:
University of Southern California - Los Angeles CA
International Classification:
A61K 3158
A61K 3156
C07J 4300
C07J 4100
Abstract:
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex.