US Patent:
20090233841, Sep 17, 2009
Inventors:
Philip S. Portoghese - St. Paul MN, US
Sandra C. Roerig - Shreveport LA, US
Assignee:
Regents of the University of Minnesota - St. Paul MN
The Board of Supervisors of the Louisiana State University and Agricultural and Mechanical College - Shreveport LA
International Classification:
A61K 38/02
A61K 31/485
C07D 491/18
C07K 2/00
A61P 25/04
US Classification:
514 2, 514282, 546 35, 530300
Abstract:
The present invention relates generally to analgesic compounds having a mu opioid receptor agonist linked to a delta opioid receptor antagonist, and to methods for producing analgesia using such compounds. As compared to opioids such as morphine, these compounds can cause less tolerance, physical dependence, and/or constipation. These compounds are also more potent than morphine and are able to cross the blood brain barrier, thereby allowing for peripheral (e.g., IV) administration.