Inventors:
Gabriel O. Reznik - Boston MA
Takeshi Sano - Needham MA
Sandor Vajda - Medfield MA
Cassandra Smith - Boston MA
Charles Cantor - Del Mar CA
Assignee:
The Trustees of Boston University - Boston MA
International Classification:
G01N 3353
US Classification:
435 75, 435 71, 435 691, 530350, 530300, 536 237, 536 231
Abstract:
Compounds and methods are described for producing streptavidin mutants with changed affinities. In particular, modifications to the sequence of the natural streptavidin gene is described to create amino acid substitutions resulting in greater affinity for biotin substitutes than for biotin.