Inventors:
Dean R. Bender - Hazlet NJ
Sandor Karady - Mountainside NJ
Theresa Rothauser - Clark NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D47108
Abstract:
(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine, and its pharmaceutically acceptable salts is useful as an anxiolytic, antidepressant, anticonvulsant, muscle relaxant and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease. The racemate of the compound is produced by a four-step synthetic process in about 65% yield from 5H-dibenzo[a,d]cyclohepten-5-one.