Ronald Keith Lattanze

20130324844, Dec 5, 2013

Mar 15, 2013

13/840925

Joshua G. Knowland - Cary NC, US
Charles W. Scarantino - Raleigh NC, US
Ronald K. Lattanze - Morrisville NC, US

A61B 6/00

600431, 600436

A system for the measurement of radiation emitted from an in-vivo administered radioactive analyte. The system employs a sensor having a scintillation material to convert gamma radiation to visible light, which enables embodiments of the sensor to be ex vivo. A light detector converts the visible light to an electrical signal. This signal is amplified and is processed to measure the captured radiation. Temperature of the sensor may be recorded along with this radiation measurement for temperature compensation of ex vivo embodiments. The sensor enables collection of sufficient data to support separate application to predictive models, background comparisons, or change analysis.

20220370024, Nov 24, 2022

May 21, 2021

17/326445

- Cary NC, US
Ronald K. Lattanze - Morrisville NC, US
Paul Mozley - Collegeville PA, US
Steven Perrin - Durham NC, US

A61B 6/00
G01T 1/20

Various embodiments of a device for in-vivo measurements radiopharmaceuticals used for diagnosis and monitoring of radiotherapy are presented. In some embodiments, the present disclosure relates to a device having a cannula that may include a measurement chamber, a radiation detector and a delivery lumen, wherein the device may be used to both deliver material to the patient (e.g., radiotracers used in radiopharmaceuticals) and measure levels and concentrations of radioactive material in, for example, the patient's blood both during and after administration of the radioactive material. In some embodiments, particles emitted by the radioactive material interact with a scintillation material, resulting in the release of light that may be transmitted, via the scintillation material and/or fiber optic material, to an optical detectors or processor for processing. In some embodiments, particle absorbing materials may be used to limit measurements to materials within the measurement chamber or other area of interest.

20210055431, Feb 25, 2021

Oct 29, 2020

17/083875

- Cary NC, US
Charles W. Scarantino - Raleigh NC, US
Ronald K. Lattanze - Morrisville NC, US

G01T 1/161
A61B 6/00
G01T 1/164

A system and method for the measurement of radiation emitted from an in-vivo administered radioactive analyte. Gamma radiation sensors may be used to determine the proper or improper administration of a radioactive analyte, and identify patient administration factors that correlate with improper administration over a set of patients so as to identify administration risk factors to improve administration of radioactive analyte. In some cases, the system employs a sensor having a scintillation material to convert gamma radiation to visible light, which enables embodiments of the sensor to be ex vivo. A light detector converts the visible light to an electrical signal. This signal is amplified and is processed to measure the captured radiation. The sensor enables collection of sufficient data to support separate application to predictive models, background comparisons, or change analysis.

20180172844, Jun 21, 2018

Jan 31, 2018

15/885112

- Cary NC, US
Charles W. Scarantino - Raleigh NC, US
Ronald K. Lattanze - Morrisville NC, US

G01T 1/161
G01T 1/164
A61B 6/00

A system and method for the measurement of radiation emitted from an in-vivo administered radioactive analyte. Gamma radiation sensors may be used to determine the proper or improper administration of a radioactive analyte. In some cases, the system employs a sensor having a scintillation material to convert gamma radiation to visible light, which enables embodiments of the sensor to be ex vivo. A light detector converts the visible light to an electrical signal. This signal is amplified and is processed to measure the captured radiation. Temperature of the sensor may be recorded along with this radiation measurement for temperature compensation of ex vivo embodiments. The sensor enables collection of sufficient data to support separate application to predictive models, background comparisons, or change analysis.

20180146936, May 31, 2018

Nov 28, 2017

15/824624

- Cary NC, US
Ronald K. Lattanze - Morrisville NC, US
Jesse Kingg - Cary NC, US
Paul Mozley - Collegeville PA, US
William Gorge - Carmel IN, US
Charles W. Scarantino - Raleigh NC, US
Steven Perrin - Raleigh NC, US

A61B 6/00
A61M 5/00
G01T 1/161
G01T 1/167

Various embodiments of a device for in-vivo measurements radiopharmaceuticals used for diagnosis and radiotherapy is presented. In some embodiments, the present disclosure relates to a scintillation device having a cannula that may include scintillation material and a delivery lumen, wherein the device may be used to both deliver material to the patient (e.g., deliver radiotracers used in radiopharmaceuticals) and measure levels of radioactive material in, for example, the patient's blood both during and after administration of the radioactive material. In some embodiments, particles emitted by the radioactive material interact with the scintillation material, resulting in the release of light that may be transmitted, via the scintillation material and/or fiber optic material, to one or more optical detectors or processors for processing. In some embodiments, particle absorbing materials may be used to reduce the effective measurement volume thereby measure only particles emitted from within a blood vessel of interest.

20160238716, Aug 18, 2016

Apr 3, 2015

14/678550

Joshua G. Knowland - Cary NC, US
Charles W. Scarantino - Raleigh NC, US
Ronald K. Lattanze - Morrisville NC, US

Lucerno Dynamics, LLC - Raleigh NC

G01T 1/161
A61B 6/00
A61B 6/03

A system and method for the measurement of radiation emitted from an in-vivo administered radioactive analyte. Gamma radiation sensors may be used to determine the proper or improper administration of a radioactive analyte in some cases, the system employs a sensor having a scintillation material to convert gamma radiation to visible light, which enables embodiments of the sensor to be ex vivo. A light detector converts the visible light to an electrical signal. This signal is amplified and is processed to measure the captured radiation. Temperature of the sensor may be recorded along with this radiation measurement for temperature compensation of ex vivo embodiments. The sensor enables collection of sufficient data to support separate application to predictive models, background comparisons, or change analysis.