US Patent:
20190016726, Jan 17, 2019
Inventors:
- South San Francisco CA, US
- Ames IA, US
Rohan Mendonca - South San Francisco CA, US
Brendan Parr - South San Francisco CA, US
Richard Pastor - South San Francisco CA, US
Zhonghua Pei - South San Francisco CA, US
Lewis Gazzard - South San Francisco CA, US
Firoz Jaipuri - Ames IA, US
Sanjeev Kumar - Ames IA, US
Xiaokai Li - Ames IA, US
Roheeth Pavana - Ames IA, US
Hima Potturi - Ames IA, US
Venkata Velvadapu - Ames IA, US
Jesse Waldo - Ames IA, US
Zuhui Zhang - Ames IA, US
Guosheng Wu - Beijing, CN
International Classification:
C07D 487/04
A61P 35/00
C07D 519/00
A61K 38/16
Abstract:
Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.