Inventors:
Brian William Pogue - Hanover NH, US
Daqing Piao - Stillwater OK, US
Keith D. Paulsen - Hanover NH, US
Shudong Jiang - Hanover NH, US
Hamid Dehghani - Exeter, GB
Heng Xu - Union City CA, US
Roger Springett - Hanover NH, US
Subhadra Srinivasan - Keene NH, US
Assignee:
The Trustees of Dartmouth College - Hanover NH
International Classification:
A61B 6/03
A61B 5/1455
Abstract:
Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.