Inventors:
Jose C. Gutierrez-Rocca - Miami FL, US
Janice L. Cacace - Miami FL, US
Sami Selim - Irvine CA, US
Robert Testman - Corona CA, US
J. Michael Rutledge - Riverdale NY, US
Assignee:
Baker Norton Pharmaceuticals, Inc. - Miami FL
International Classification:
A61K031/337
Abstract:
Pharmaceutical compositions for oral administration to mammalian subjects comprise a taxane or taxane derivative (e. g. , paclitaxel or docetaxel) as active ingredient and a vehicle comprising at least 30% by weight of a carrier for the taxane, said carrier having an HLB value of at least about 10. The compositions may also comprise 0–70% of a viscosity-reducing co-solubilizer. The compositions may be incorporated into conventional oral pharmaceutical dosage forms, or can be in the form of a two-part medicament wherein the first part includes the taxane in a solubilizing vehicle and the second part comprises a carrier for the taxane to promote oral absorption. Methods of treatment of taxane-responsive disease conditions employing the novel compositions are also disclosed, whereby the compositions can be administered alone or in association with an oral bioavailability enhancing agent.