Inventors:
Vladimir Torchilin - Charlestown MA, US
Rishikesh Sawant - Boston MA, US
Amit Kale - Boston MA, US
International Classification:
A61K 31/50
A01N 1/00
A61K 31/70
A61K 38/00
A61K 39/395
A61K 49/00
A61P 43/00
US Classification:
424152100, 424130100, 424009100, 435001100, 514002000, 514249000, 514044000
Abstract:
A condition-dependent, multiple target delivery system providing multifunctional, stimuli-sensitive pharmaceutical carriers is disclosed. The delivery system simultaneously carries on its surface various active moieties. The system is multifunctional and possesses the ability to switch on and switch off certain functions when necessary, for example, under the action of local stimuli characteristic of the target pathological zone (e.g., increased temperature or lowered pH values, which are characteristic of inflamed, ischemic and neoplastic tissues).