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Richard M Soll

from Middleton, MA
Age ~68
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Also known as:
Richard Dr Soll, Richard Mi Soll, Richard F Soll, Richard N Soll, Rick M Soll, Dick M Soll, Richard M Solt, Richard R
Related to:
Meryl H FranzoneLarry SaulAdam SollJacob Soll, 96Fay SollAlexa Heitmann, 37
Connected to:
Amy H Soll, 62Ashley M Soll, 34Damian A Soll, 42Joan R Soll, 75Kathleen D Soll, 62Ralph A Soll, 58Alicia Solla, 29April M Solla, 38Carmen A Solla, 51Fernando F Solla, 95

Richard Soll Phones & Addresses

  • Middleton, MA
  • Boynton Beach, FL
  • Andover, MA
  • 5519 Caminito Mundano, San Diego, CA 92130 (858) 523-1354
  • 324 Glenn Ave, Trenton, NJ 08648 (609) 883-1416
  • Lawrence Township, NJ
  • Carlsbad, CA

Publications

Us Patents

Benzamide And Sulfonamide Substituted Aminoguanidines And Alkoxyguanidines As Protease Inhibitors

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US Patent:
6274628, Aug 14, 2001
Filed:
Apr 1, 1999
Appl. No.:
9/283241
Inventors:
Richard M. Soll - Lawrenceville NJ
Tianbao Lu - Collegeville PA
Bruce E. Tomczuk - Collegeville PA
Thomas P. Markotan - Morgantown PA
Colleen Siedem - Kennett Square PA
Assignee:
3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
A61K 31165
A61K 31435
US Classification:
514620
Abstract:
The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: ##STR1## wherein X is O or NH, L is --O-- or --SO. sub. 2 --, and R. sup. 1 -R. sup. 4, R. sup. 9 -R. sup. 19, R. sup. a, R. sup. b, R. sup. c, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing the compounds of Formula I. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are intermediates useful for forming compounds having antithrombotic activity. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage.

Benzamide And Sulfonamide Substitued Aminoguanidines And Alkoxyguanidines As Protease Inhibitors

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US Patent:
6344466, Feb 5, 2002
Filed:
Feb 28, 2001
Appl. No.:
09/796319
Inventors:
Richard M. Soll - Lawrenceville NJ
Tianbao Lu - Collegevile PA
Bruce E. Tomczuk - Collegevile PA
Thomas P. Markotan - Morgantown PA
Colleen Siedem - Kennett Square PA
Assignee:
3-Dimensional Pharmaceuticals Inc. - Exton PA
International Classification:
A61K 31445
US Classification:
514331, 5142378, 51421711, 51425212, 51425301, 51425503, 514307, 540607, 544162, 544360, 544386, 544387, 546145, 546226
Abstract:
The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: wherein X is O or NH, L is âOâ or âSO â, and R -R , R -R , R , R , R , Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing the compounds of Formula I. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are intermediates useful for forming compounds having antithrombotic activity. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage.

Radiolabeled 1-Aryl Pyrazoles, The Synthesis Thereof And The Use Thereof As Pest Gaba Receptor Ligands

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US Patent:
6409988, Jun 25, 2002
Filed:
Jun 29, 2000
Appl. No.:
09/606051
Inventors:
Daljit S. Dhanoa - West Chester PA
Sanath Meegalla - Devon PA
Dario Doller - Branford CT
Richard M. Soll - Lawrenceville NJ
Assignee:
3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
A61K 5100
US Classification:
424 181, 5483771
Abstract:
The present invention is directed to radiolabeled compounds of Formula I: or salts thereof, where R represents R , R O, R SO , R SO or R S in which R is tritiated or deuterated methyl; X is halo, cyano, C alkoxycarbonyl, C alkynyl, optionally substituted C aryl or an optionally substituted 5- to 7-membered heteroaromatic ring linked to thiazole via a carbon-carbon bond; R is hydrogen or amino; and R -R are defined in the specification. The invention is also directed to methods of using such compounds for demonstrating specific insect GABA receptors, qualitatively screening for compounds acting on an insect GABA receptor or quantitatively assaying concentrations of a compound acting on an insect GABA receptor.

Amidino Protease Inhibitors

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US Patent:
6414020, Jul 2, 2002
Filed:
May 9, 2001
Appl. No.:
09/851123
Inventors:
Tianbao Lu - Exton PA
Bruce E. Tomczuk - Collegeville PA
Carl R. Illig - Phoenixville PA
Richard M. Soll - Lawrenceville NJ
Assignee:
3- Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
A61K 31155
US Classification:
514517, 514518, 514602, 514603, 514604, 514605, 514637, 558 56, 558 58, 564 85, 564 86, 564 92, 564 99, 564244, 564246, 564247
Abstract:
Amidino and benzamidino compounds, including compounds of the formula: wherein R -R , R -R , Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.

Amino Acid Amidinohydrazones, Alkoxyguanidines And Aminoguanidines As Protease Inhibitors

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US Patent:
6417161, Jul 9, 2002
Filed:
Apr 22, 1999
Appl. No.:
09/296296
Inventors:
Tianbao Lu - Collegeville PA
Bruce E. Tomczuk - Collegeville PA
Thomas P. Markotan - Morgantown PA
Richard M. Soll - Lawrenceville NJ
Assignee:
3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
A61K 3805
US Classification:
514 2, 514 19, 514 20, 514349, 5462837, 546297
Abstract:
The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: wherein X is O or NR and A , A , R -R , R , R , R , R , n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing the compounds of Formula I. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are intermediates useful for forming compounds having antithrombotic activity. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage.

Heteroaryl Protease Inhibitors And Diagnostic Imaging Agents

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US Patent:
6420397, Jul 16, 2002
Filed:
Jul 7, 2000
Appl. No.:
09/612591
Inventors:
Wenxi Pan - Exton PA
Tianbao Lu - Collegeville PA
Richard M. Soll - Lawrenceville NJ
Bruce E. Tomczuk - Collegeville PA
Assignee:
3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
A61K 314412
US Classification:
514352, 514357, 514365, 514374, 5462682, 5462697, 5462714
Abstract:
Ketothiazole alkoxyguanidine and aminoguanidine analogs are described, including compounds of the Formula I: wherein X is O or NR and Het, A, R , R , R , R , R , R , R , R , Z, m and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

System, Method And Computer Program Product For Identifying Chemical Compounds Having Desired Properties

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US Patent:
6421612, Jul 16, 2002
Filed:
Nov 4, 1997
Appl. No.:
08/963870
Inventors:
Dimitris K. Agrafiotis - Downington PA
Roger F. Bone - Bridgewater NJ
Francis R. Salemme - Yardley PA
Richard M. Soll - Lawrenceville NJ
Assignee:
3-Dimensional Pharmaceuticals Inc. - Exton PA
International Classification:
G06F 1900
US Classification:
702 19
Abstract:
An automatic, partially automatic, and/or manual iterative system, method and/or computer program product for generating chemical entities having desired or specified physical, chemical, functional, and/or bioactive properties. The present invention identifies a set of compounds for analysis; collects, acquires or synthesizes the identified compounds; analyzes the compounds to determine one or more physical, chemical and/or bioactive properties (structure-property data); and uses the structure-property data to identify another set of compounds for analysis in the next iteration. An Experiment Planner generates Selection Criteria and/or one or more Objective Functions for use by a Selector. The Selector searches the Compound Library to identify a subset of compounds (a Directed Diversity Library) that maximizes or minimizes the Objective Functions. The compounds listed in the Directed Diversity Library are then collected, acquired or synthesized, and are analyzed to evaluate their properties of interest. In one embodiment, when a compound in a Directed Diversity Library is available in a Chemical Inventory, the compound is retrieved from the Chemical Inventory instead of re-synthesizing the compound.

Method Of Generating Chemical Compounds Having Desired Properties

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US Patent:
6434490, Aug 13, 2002
Filed:
Dec 17, 1998
Appl. No.:
09/213156
Inventors:
Dimitris K. Agrafiotis - Exton PA
Roger F. Bone - Bridgewater NJ
Francis R. Salemme - Kennett Square PA
Richard M. Soll - Lawrenceville NJ
Assignee:
3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
G01N 3100
US Classification:
702 27, 435 724, 435 691, 435 912
Abstract:
A computer based, iterative process for generating chemical entities with defined physical, chemical and/or bioactive properties. During each iteration of the process, (1) a directed diversity chemical library is robotically generated in accordance with robotic synthesis instructions; (2) the compounds in the directed diversity chemical library are analyzed to identify compounds with the desired properties; (3) structure-property data are used to select compounds to be synthesized in the next iteration; and (4) new robotic synthesis instructions are automatically generated to control the synthesis of the directed diversity chemical library for the next iteration.
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Richard M Soll from Middleton, MA, age ~68 Get Report