Richard Dennis Peindl

20090155908, Jun 18, 2009

Dec 17, 2007

11/957747

Craig HALBERSTADT - Charlotte NC, US
Richard Peindl - Huntersville NC, US

C12N 5/06
C12M 1/00

435397, 4352891, 4352971, 4352972, 4352865

Apparatuses, systems, and methods are provided for growing and maintaining cells. A three-dimensional matrix, such as a hydrogel material, is seeded with cells and placed in a bioreactor having two compartments. The matrix is supported between the two compartments by first and second porous materials, which engage opposing surfaces of the matrix. A first media stream having certain properties is propagated through the first compartment, where it contacts one surface of the matrix via the first porous material. A second media stream having different properties is propagated through the second compartment such that it contacts the opposite surface of the matrix via the second porous material. Through migration of each stream at least partially into the matrix, various controlled gradients may be established within the matrix, encouraging growth of the cells. Such gradients include osmotic pressure, oscillating osmotic pressure, hydrostatic pressure, oxygen tension, and/or nutrient gradients.

54719968, Dec 5, 1995

Sep 30, 1993

8/130108

James R. Boatright - Charlotte NC
Richard D. Peindl - Charlotte NC

Charlotte-Mecklenburg Hospital Authority - Charlotte NC

A62B 500

128782

An apparatus and method for measuring abduction strength of a patient's thumb. The apparatus includes a frame for receiving the patient's hand thereupon in a longitudinal direction, enabling the thumb of the patient to move freely upwardly and downwardly about the joint at the base of the thumb. A thumb engaging means is pivotally mounted to the frame for engaging the patient's thumb assuring the upward and downward movement thereof. The thumb engaging means is pivotal about a transverse axis. A force transducer means is mounted to the thumb engaging means for detecting the force transmitted between the thumb engaging means and the patient's thumb. The force transducer means produces an output representative of the detected force. A display means is provided for displaying the received output.

59689994, Oct 19, 1999

Oct 28, 1997

8/959498

Warren Kibby Ramp - Charlotte NC
Richard Dennis Peindl - Huntersville NC

Charlotte-Mecklenburg Hospital Authority - Charlotte NC

A61K 608

523116

There is provided a polymethylmethacrylate (PMMA) bone cement composition that includes the addition of from about 10% by weight to about 30% by weight of calcium hydroxide. The bone cement is used for orthopaedic procedures, injuries, or disease states that have compromised the metabolism of local hard and soft tissues, largely due to an acidic environment. In an aqueous environment, the calcium hydroxide is slowly released from pores in the polymer matrix as calcium and hydroxyl ions to provide a method for stimulating healing by maintaining or elevating local pH in the tissues adjacent to bone cement. It has also been found that the calcium hydroxide ameliorates the toxic effects of antibiotics which are often included in the bone cement.

56625910, Sep 2, 1997

May 26, 1995

8/451173

Richard D. Peindl - Charlotte NC
Melissa Lee McCarthy - Baltimore MD
Ellen Jane MacKenzie - Baltimore MD

The Johns Hopkins University - Baltimore MD
The Charlotte-Mecklenburg Hospital Authority - Charlotte NC

A61B 5103

601 24

An apparatus for measuring the strength of and for performing physical therapy exercises to strengthen a patient's limb. The device includes a pair of pivot clamps each having a end for connecting the pivot clamps to a solid object such as a physical therapy table or hospital bed. A second end of each pivot clamp adjustably receives a first frame member of a conventional traction or load frame. This arrangement enables rotational and translational movement of the first frame member retained by the pivot clamp relative to each pivot clamp to allow the frame to be positioned in a desired location and orientation relative to the patient's limb to be tested. A second frame member is adjustably connected to the pair of first frame members by a pair of adjustable brackets. A limb engaging member having a force transducer located therein is used to both engage the patient's limb to be tested and to detect a force transmitted between the limb of a patient and the limb engaging member. The force transducer produces an output which is representative of the force produced which may be displayed on a digital panel meter.

56353901, Jun 3, 1997

Apr 17, 1996

8/642122

Richard D. Peindl - Charlotte NC
Warren K. Ramp - Charlotte NC

Charlotte-Mecklenburg Hospital Authority - Charlotte NC

C12M 300
C12N 506

435402

A cell culture apparatus includes a substrate, and an inorganic film on the substrate and having a relatively smooth surface for cell growth thereon. Moreover, the relatively smooth surface has a relatively low predetermined surface roughness so that cells grown thereon adhere by chemical adhesion rather than by mechanical interlocking. In other words, the predetermined surface roughness defines surface indentations smaller than a size of corresponding cells to be grown thereon. Accordingly, the interaction between various inorganic materials and cells may be studied based upon chemical adhesion rather than mechanical interlocking. The predetermined surface roughness is preferably less about 10. mu. m root-mean-square, and more preferably less than about 1. mu. m root-mean-square.

55388876, Jul 23, 1996

Feb 18, 1994

8/198982

Richard D. Peindl - Charlotte NC
Warren K. Ramp - Charlotte NC

Charlotte-Mecklenburg Hospital Authority - Charlotte NC

C12M 300

435240243

A cell culture apparatus includes a substrate, and an inorganic film on the substrate and having a relatively smooth surface for cell growth thereon. Moreover, the relatively smooth surface has a relatively low predetermined surface roughness so that cells grown thereon adhere by chemical adhesion rather than by mechanical interlocking. In other words, the predetermined surface roughness defines surface indentations smaller than a size of corresponding cells to be grown thereon. Accordingly, the interaction between various inorganic materials and cells may be studied based upon chemical adhesion rather than mechanical interlocking. The predetermined surface roughness is preferably less about 10. mu. m root-mean-square, and more preferably less than about 1. mu. m root-mean-square.

20140377867, Dec 25, 2014

Sep 5, 2014

14/478270

- Charlotte NC, US
Richard Peindl - Huntersville NC, US

C12N 5/077
C12M 1/00
C12M 3/00

435397, 4352941

Apparatuses, systems, and methods are provided for growing and maintaining cells. A three-dimensional matrix, such as a hydrogel material, is seeded with cells and placed in a bioreactor having two compartments. The matrix is supported between the two compartments by first and second porous materials, which engage opposing surfaces of the matrix. A first media stream having certain properties is propagated through the first compartment, where it contacts one surface of the matrix via the first porous material. A second media stream having different properties is propagated through the second compartment such that it contacts the opposite surface of the matrix via the second porous material. Through migration of each stream at least partially into the matrix, various controlled gradients may be established within the matrix, encouraging growth of the cells. Such gradients include osmotic pressure, oscillating osmotic pressure, hydrostatic pressure, oxygen tension, and/or nutrient gradients.