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Richard A Flavell

from Guilford, CT
Age ~78
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Also known as:
Richard Anthony Dr Flavell, Richard Anthony Flavell, Rick A Flavell, Dick A Flavell
Phone and address:
283 Moose Hill Rd, Guilford, CT 06437
(203) 453-4040
Related to:
Steven Willem Flavell, 44
Connected to:
Amy J Flavell, 27Carl J Flavell, 44Emily Flavell, 33Joshua R Flavell, 30Michele L Flavell, 52Mary T Flaven, 58Thomas Flaven, 48Daphne D Flavia, 45Eva B Flaviani, 91Nicholas R Flaviano, 68

Richard Flavell Phones & Addresses

  • 283 Moose Hill Rd, Guilford, CT 06437 (203) 453-4040
  • Florence, OR
  • Auburndale, MA
  • 182 Reservoir Rd, Killingworth, CT 06419
  • Deep River, CT
  • Sudbury, MA
  • Lime, OR
  • 275 Morse Rd, Sudbury, MA 01776

Work

Company: Cellmates 1992 to 2012 Position: Janitor

Education

School / High School: The University of Hull 1964 to 1970

Skills

Immunology • Molecular Biology • Cell Biology • Biochemistry • Lifesciences • Drug Discovery • Biotechnology • Cell Culture • Cell • Cancer • Neuroscience • Protein Expression • Genomics • Drug Development • In Vivo • Genetics • Science • Immunohistochemistry • Flow Cytometry • Protein Chemistry • Animal Models • In Vitro • Life Sciences

Industries

Research

Resumes

Resumes

Richard Flavell Photo 1

Investigator And Sterling Professor And Chairman

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Location:
New Haven, CT
Industry:
Research
Work:
Cellmates 1992 - 2012
Janitor
Biogen 1982 - 1988
Chief Strategy Officer
Biogen Idec 1982 - 1988
Chief Strategy Officer
Yale University 1982 - 1988
Investigator and Sterling Professor and Chairman
Education:
The University of Hull 1964 - 1970
Hamond's Grammar School
Skills:
Immunology
Molecular Biology
Cell Biology
Biochemistry
Lifesciences
Drug Discovery
Biotechnology
Cell Culture
Cell
Cancer
Neuroscience
Protein Expression
Genomics
Drug Development
In Vivo
Genetics
Science
Immunohistochemistry
Flow Cytometry
Protein Chemistry
Animal Models
In Vitro
Life Sciences

Business Records

Name / Title
Company / Classification
Phones & Addresses
Richard Flavell
Chairman, Professor
Immune Disease Institute
Noncommercial Research Organization · Medical Laboratory
200 Longwood Ave, Boston, MA 02115
3 Blackfan Cir, Boston, MA 02115
(617) 713-8000, (617) 713-8540
Richard Flavell
Chief Scientific Officer
CERES, INC
Civic/Social Association · Environmental Conservation/Eco
99 Chauncy St STE 601, Boston, MA 02111
(617) 247-0700, (857) 277-6455, (617) 267-5400

Publications

Us Patents

Compositions And Methods Comprising Dna Sequences Encoding B. Burgdorferi Polypeptides

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US Patent:
6344552, Feb 5, 2002
Filed:
May 31, 1995
Appl. No.:
08/455973
Inventors:
Richard A. Flavell - Killingworth CT
Fred S. Kantor - Orange CT
Stephen W. Barthold - Madison CT
Erol Fikrig - Guilford CT
Assignee:
Yale University - New Haven CT
International Classification:
A61K 3902
US Classification:
536 237, 536 234, 4352523, 4353201, 435 691, 435 693, 435 711, 435 712, 4242031, 4242001, 4241901, 4241921, 4241841, 4241851
Abstract:
Methods and compositions for the prevention and diagnosis of Lyme disease. OspA and OspB polypeptides and serotypic variants thereof, which elicit in a treated animal the formation of an immune response which is effective to treat or protect against Lyme disease as caused by infection with. Anti-OspA and anti-OspB antibodies that are effective to treat or protect against Lyme disease as caused by infection with. A screening method for the selection of those OspA and OspB polypeptides and anti-OspA and anti-OspB antibodies that are useful for the prevention and detection of Lyme disease. Diagnostic kits including OspA and OspB polypeptides or antibodies directed against such polypeptides.

B. Burgdorferi Polypeptides

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US Patent:
6716591, Apr 6, 2004
Filed:
Sep 14, 1998
Appl. No.:
09/152588
Inventors:
Richard A. Flavell - Killingworth CT
Erol Fikrig - Guilford CT
Tuan T. Lam - San Jose CA
Fred S. Kantor - Orange CT
Stephen W. Barthold - Madison CT
Assignee:
Yale University - New Haven CT
International Classification:
G01N 3353
US Classification:
435 722, 435 71, 435 72, 530350, 5303871, 5303891
Abstract:
Methods and compositions for the prevention, treatment and diagnosis of Lyme disease. Novel polypeptides, serotypic variants thereof, fragments thereof and derivatives thereof. Fusion proteins and multimeric proteins comprising same. Multicomponent vaccines comprising novel polypeptides in addition to other immunogenic polypeptides. DNA sequences, recombinant DNA molecules and transformed host cells useful in the compositions and methods. Antibodies directed against the novel polypeptides, and diagnostic kits comprising the polypeptides or antibodies.

Compositions And Methods Relating To Glucose Metabolism, Weight Control, And Food Intake

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US Patent:
6861405, Mar 1, 2005
Filed:
Jun 11, 2002
Appl. No.:
10/167528
Inventors:
Gary Desir - Woodbridge CT, US
Jianchao Xu - Bethany CT, US
Pandelakis A. Koni - Martinez GA, US
Leonard Kaczmarek - Guilford CT, US
Richard A. Flavell - Guilford CT, US
Assignee:
Yale University - New Haven CT
International Classification:
A61K038/17
US Classification:
514 12
Abstract:
The present invention relates to weight control, control of body fat and food intake, and provides useful methods for treating, inter alia, obesity, diabetes and insulin insensitivity, and conditions, diseases, and disorders relating thereto. The invention also relates to methods of identifying useful compounds relating to weight loss, food intake, diabetes, and obesity, among other things, based on the discovery that inhibiting Kv1. 3 activity mediates decreased food intake, weight loss, decreased body fat, increase glucose uptake, and increased insulin sensitivity, among other things.

Universal Donor Cells

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US Patent:
6916654, Jul 12, 2005
Filed:
May 5, 2000
Appl. No.:
09/566254
Inventors:
Peter J. Sims - Mequon WI, US
Alfred L. M. Bothwell - Guilford CT, US
Eileen A. Elliot - New Haven CT, US
Richard A. Flavell - Killingworth CT, US
Joseph Madri - North Branford CT, US
Scott Rollins - Monroe CT, US
Leonard Bell - Woodbridge CT, US
Stephen Squinto - Irvington NY, US
Assignee:
Oklahoma Medical Research Foundation - Oklahoma City OK
Yale University - New Haven CT
International Classification:
C12N005/10
C12N015/63
A61K048/00
A01N067/027
US Classification:
435325, 4353201, 435455, 800 8, 800 13, 800 18, 514 44
Abstract:
Genetically engineered cells are provided which can serve as universal donor cells in such applications as reconstruction of vascular linings or the administration of therapeutic agents. The cells include a coding region which provides protection against complement-based lysis, i. e. , hyperacute rejection. In addition, the cell's natural genome is changed so that functional proteins encoded by either the class II or both the class I and the class II major histocompatibility complex genes do not appear on the cell's surface. In this way, attack by T-cells is avoided. Optionally, the cells can include a self-destruction mechanism so that they can be removed from the host when no longer needed.

Jnk3 Modulators And Methods Of Use

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US Patent:
6943000, Sep 13, 2005
Filed:
Oct 2, 1998
Appl. No.:
09/165522
Inventors:
Roger J. Davis - Princeton MA, US
Richard A. Flavell - Guilford CT, US
Pasko Rakic - New Haven CT, US
Alan J. Whitmarsh - Shrewsbury MA, US
Chia-Yi Kuan - Wallingford CT, US
Derek Di Yang - Carmel IN, US
Assignee:
University of Massachusetts - Boston MA
Yale University - New Haven CT
International Classification:
C12N009/00
C12N009/12
C12P021/06
C12Q001/48
C07H021/04
US Classification:
435194, 435 4, 435 6, 435 15, 435 691, 435183, 435193, 536 232, 536 234, 536 235
Abstract:
The c-Jun NH-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.

Genetically Altered Mice Deficient In Functional Caspase-9

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US Patent:
7323616, Jan 29, 2008
Filed:
Dec 1, 2000
Appl. No.:
09/728173
Inventors:
Keisuke Kuida - Lexington MA, US
Richard A. Flavell - Guilford CT, US
Assignee:
Vertex Pharmaceuticals, Inc. - Cambridge MA
Yale University - New Haven CT
International Classification:
A01K 67/027
A01K 67/063
G01N 33/00
C12N 15/00
US Classification:
800 18, 800 3, 800 9, 800 25
Abstract:
The invention relates to genetically manipulated animals that are deficient in the expression of Caspase-9, a protein involved in programmed cell death. The invention further relates to methods for preventing specific types of cell death associated with Caspase-9 activation.

Genetically Modified Mice And Engraftment

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US Patent:
8541646, Sep 24, 2013
Filed:
Oct 4, 2010
Appl. No.:
12/897517
Inventors:
Sean Stevens - San Diego CA, US
Andrew J. Murphy - Croton-on-Hudson NY, US
Richard Flavell - Guilford CT, US
Elizabeth Eynon - New Haven CT, US
Jorge Galan - New Haven CT, US
Tim Willinger - New Haven CT, US
Markus Manz - Zurich, CH
Anthony Rongvaux - New Haven CT, US
George D. Yancopoulos - Yorktown Heights NY, US
Assignee:
Regeneron Pharmaceuticals, Inc. - Tarrytown NY
Yale University - New Haven CT
Institute for Research in Biomedicine - Bellinzona
International Classification:
A01K 67/027
G01N 33/00
US Classification:
800 18, 800 3, 800 8, 800 13, 800 14
Abstract:
A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e. g. , or is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e. g. , a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e. g. , a myeloid leukemia or a myeloproliferative neoplasia.

Irak-M Is A Negative Regulator Of Toll-Like Receptor Signaling

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US Patent:
20030157539, Aug 21, 2003
Filed:
Jan 9, 2003
Appl. No.:
10/340545
Inventors:
Richard Flavell - Guilford CT, US
Koichi Kobayashi - Branford CT, US
Ruslan Medzhitov - Branford CT, US
Assignee:
Yale University - New Haven CT
International Classification:
C12Q001/68
C07H021/04
C12P021/02
C12N005/06
C07K014/705
US Classification:
435/006000, 435/069100, 435/320100, 435/325000, 530/350000, 536/023200
Abstract:
Isolated nucleic acid encoding the amino acid sequence of murine IRAK-M; expression vectors comprising nucleic acid encoding IRAK-M and host cells comprising them are disclosed. IRAK-M is induced upon toll-like receptor (TLR) stimulation and negatively regulates TLR signaling. Methods for identifying antagonists and agonists of IRAK-M are described.

Isbn (Books And Publications)

Modelling Reality and Personal Modelling

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Author

Richard Flavell

ISBN #

0387914463

Swaps and Other Derivatives

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Author

Richard Flavell

ISBN #

0470867485

Swaps and Other Derivatives

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Author

Richard Flavell

ISBN #

0471495891

Wikipedia References

Richard Flavell Photo 2

Richard Flavell

Work:
Company:

Yale School of Medicine

Position:

Investigator

Education:
Studied at:

University of Hull

Academic degree:

Member of the United States National Academy of Sciences • Professor

Specialty:

Biochemist

Skills & Activities:
Award:

Commander of the Order of the British Empire

Ascribed status:

Fellow of the Royal Society

Richard Flavell Photo 3

Richard B . Flavell

About:
Born:

1943

Education:
Studied at:

University of Birmingham • University of East Anglia

Academic degree:

Academics of the University of East Anglia • Professor

Specialty:

Director • Molecular biologist

Skills & Activities:
Ascribed status:

Fellow of the Royal Society

Award:

Commander of the Order of the British Empire

Skill:

Scientific

Richard Flavell Photo 4

Richard A. Flavell

Richard Flavell Photo 5

Richard B. Flavell

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Richard A Flavell from Guilford, CT, age ~78 Get Report