Reem M Haidar

6043272, Mar 28, 2000

Nov 20, 1997

8/975391

Carlo Brugnara - Newton Highlands MA
Jose Halperin - Brookline MA
Rudolf Fluckiger - Brookline MA
Emile Bellot - Beverly MA
Richard John Lombardy - Littleton MA
John J. Clifford - Arlington MA
Reem M. Haidar - Woburn MA
Eugene W. Kelleher - Somerville MA
Adel M. Moussa - Burlington MA
Yesh P. Sachdeva - Concord MA
Minghua Sun - Libertyville IL
Heather N. Taft - Littleton MA

Ion Pharmaceuticals, Inc. - New York NY
President and Fellows of Harvard College - Cambridge MA
Children's Medical Center Corporation - Boston MA

A61K 31335
C07C25500
C07C 6976
C07C 6952

514467

The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

6534497, Mar 18, 2003

Sep 22, 2000

09/554848

Carlo Brugnara - Newton Highlands MA
Jose Halperin - Brookline MA
Rudolf Fluckiger - Brookline MA
Richard John Lombardy - Littleton MA
John J. Clifford - Bedford MA
Reem M. Haidar - Woburn MA
Eugene W. Kelleher - Somerville MA
Adel M. Moussa - Burlington MA
Yesh P. Sachdeva - Concord MA
Minghua Sun - Cambridge MA
Heather N. Taft - Littleton MA
Michael H. Zeldin - Cambridge MA

Nuchem Pharmaceuticals, Inc. - Markham
Childrens Medical Center Corporation - Boston MA
Presidents and Fellows of Harvard College - Cambridge MA

C07D22320

514217, 540587

The present invention provides substituted 11-phenyl-dibenzazepine compounds that are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

6800658, Oct 5, 2004

Jan 10, 2002

10/043640

Carlo Brugnara - Newton Highlands MA
Jose Halperin - Brookline MA
Rudolf Fluckiger - Brookline MA
Richard John Lombardy - Littleton MA
John J. Clifford - Arlington MA
Reem M. Haidar - Woburn MA
Eugene W. Kelleher - Somerville MA
Adel M. Moussa - Burlington MA
Yesh P. Sachdeva - Concord MA
Minghua Sun - Cambridge MA
Heather N. Taft - Littleton MA

Childrens Medical Center Corporation - Cambridge MA
President Fellows of Harvard College - Cambridge MA
Nuchem Pharmaceuticals, Inc.

C07C 2200

514467, 514475, 514544, 514546, 514640, 514617, 514717, 549430, 549453, 549550, 558388, 560 56, 560 57, 560221, 564180, 564265

The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

6992079, Jan 31, 2006

Dec 7, 2001

10/013308

Carlo Brugnara - Newton Highlands MA, US
Jose Halperin - Brookline MA, US
Rudolf Fluckiger - Brookline MA, US
Richard John Lombardy - Littleton MA, US
John J. Clifford - Arlington MA, US
Reem M. Haidar - Woburn MA, US
Eugene W. Kelleher - Medford MA, US
Adel M. Moussa - Burlington MA, US
Yesh P. Sachdeva - Concord MA, US
Minghua Sun - Libertyville IL, US
Heather N. Taft - Littleton MA, US
Michael H. Zeldin - Cambridge MA, US

President Fellows of Harvard College - Cambridge MA
Children's Medical Center Corporation - Boston MA
NuChem Pharmaceuticals Inc. - Toronto

A61K 31/55
C07D 233/18

514217, 540587

The present invention provides substituted 11-phenyl-dibenzazepine compounds which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

7342038, Mar 11, 2008

Jun 1, 2004

10/858975

Carlo Brugnara - Newton Highlands MA, US
Jose Halperin - Brookline MA, US
Rudolf Fluckiger - Brookline MA, US
Richard John Lombardy - Littleton MA, US
John J. Clifford - Bedford MA, US
Reem M. Haidar - Woburn MA, US
Eugene W. Kelleher - Somerville MA, US
Adel M. Moussa - Burlington MA, US
Yesh P. Sachdeva - Concord MA, US
Minghua Sun - Cambridge MA, US
Heather N. Taft - Littleton MA, US

President and Fellow of Harvard College - Cambridge MA
Children's Medical Center Corporation - Boston MA
NuChem Pharmaceuticals Inc. - Toronto

C07D 209/10
C07D 209/12
A61K 31/404

514415, 548469, 548483, 548490

The present invention provides substituted 3,3-diphenyl indole compounds, as well as analogues thereof, which are specific potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

7531573, May 12, 2009

Jun 3, 2003

10/454372

Carlo Brugnara - Newton Highlands MA, US
Jose Halperin - Brookline MA, US
Mark Froimowitz - Newton Centre MA, US
Richard John Lombardy - Littleton MA, US
John J. Clifford - Bedford MA, US
Reem M. Haidar - Woburn MA, US
Eugene W. Kelleher - Bedford MA, US
Falguni M. Kher - Billerica MA, US
Adel M. Moussa - Burlington MA, US
Yesh P. Sachdeva - Concord MA, US
Minghua Sun - Libertyville IL, US
Heather N. Taft - Littleton MA, US

Children's Medical Center Corporation - Boston MA

A61K 31/275

514519, 514520, 514521

The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.

20020119953, Aug 29, 2002

Aug 28, 2001

09/942258

Carlo Brugnara - Newton Highlands MA, US
Jose Halperin - Brookline MA, US
Emile Bellott - Beverly MA, US
Mark Froimowitz - Newton Centre MA, US
Richard Lombardy - Littleton MA, US
John Clifford - Arlington MA, US
Reem Haidar - Lexington MA, US
Eugene Kelleher - Medford MA, US
Falguni Kher - Billerica MA, US
Adel Moussa - Burlington MA, US
Yesh Sachdeva - Concord MA, US
Minghua Sun - Libertyville IL, US
Heather Taft - Littleton MA, US

A61K031/695
A61K031/675
A61K031/66
A61K031/555
A61K031/41

514/063000, 514/079000, 514/114000, 514/184000, 514/359000, 514/492000, 514/642000, 514/626000, 514/519000, 514/513000

The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.

20020128256, Sep 12, 2002

Jun 13, 2001

09/880728

Carlo Brugnara - Newton Highlands MA, US
Jose Halperin - Brookline MA, US
Rudolf Fluckiger - Brookline MA, US
Emile Bellott - Beverly MA, US
Richard Lombardy - Littleton MA, US
John Clifford - Arlington MA, US
Reem Haidar - Lexington MA, US
Eugene Kelleher - Medford MA, US
Adel Moussa - Burlington MA, US
Yesh Sachdeva - Concord MA, US
Minghua Sun - Libertville IL, US
Heather Taft - Littleton MA, US

A61K031/55
A61K031/4747
A61K031/407
A61K031/405
A61K031/277
A61K031/235
A61K031/165

514/212020, 514/278000, 514/409000, 514/415000, 514/513000, 514/532000, 514/519000, 514/618000, 514/619000

The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof which are specific, potent and safe inhibitors of the Ca-activated potassium channel (Gardos channel) of erythrocytes. The compounds can be used as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation.