US Patent:
20070010477, Jan 11, 2007
Inventors:
Bruce Dolnick - Orchard Park NY, US
Janice Sufrin - Snyder NY, US
Norman Angelino - Amherst NY, US
Ree Dolnick - Orchard Park NY, US
Lawrence Stephanie - Rochester MN, US
Colin Oliver - Buffalo NY, US
International Classification:
A61K 31/7072
A61K 31/513
A61K 31/365
A61K 31/337
US Classification:
514049000, 514471000, 514473000, 514449000, 514269000
Abstract:
The present invention provides a method for inhibiting the growth of cancer cells using AHLs of the general formula CX-homoserine lactone where “X” represents a number of between 5 and 14 carbon atoms in the acyl chain of the AHL. The method comprises the step of administering to an individual an amount of an AHL effective to inhibit the growth of cancer cells. Also provided is a method for enhancing the effect of a chemotherapeutic agent comprising the step of administering to an individual the chemotherapeutic agent and an amount of an AHL effective to enhance the cancer cell growth inhibitory effect of the chemotherapeutic agent.